Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study

Vaca Jessica; Salazar Francisco; Ortiz Aurelio; Sansinenea Estibaliz

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study

机译：吲哚生物碱衍生物作为来自芽孢杆菌和芽孢杆菌的天然产物的结构块及其抗菌和抗真菌活性研究

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Six known indole alkaloid derivatives have been isolated for the first time from Bacillus thuringiensis and Bacillus velezensis strains, all of them as building blocks for the synthesis of larger natural products. Their structure was elucidated by a complete spectroscopy. Their biological activities were tested against some Gram-positive and Gram-negative bacteria and three phytopathogenic fungi which cause diseases in important crops, such as Moniliophthora roreri, the causal agent of cacao disease. The results indicated that some compounds had modest antibacterial activity; however, some of them had strong antifungal activity against the probed fungi. This antifungal activity of these compounds has not been reported.

机译：六种已知的吲哚生物碱衍生物首次从苏云金芽孢杆菌和velezensis杆菌菌株中分离出来，它们都是合成更大天然产物的基础。它们的结构由一个完整的光谱仪来阐明。对一些革兰氏阳性菌和革兰氏阴性菌以及三种在重要作物中引起疾病的植物病原真菌，如引起可可病害的念珠菌进行了生物活性测试。结果表明，部分化合物具有一定的抗菌活性；然而，其中一些对所检测的真菌具有较强的抗真菌活性。这些化合物的这种抗真菌活性尚未见报道。

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《The Journal of Antibiotics: An International Journal》 |2020年第11期|共5页
作者
Vaca Jessica; Salazar Francisco; Ortiz Aurelio; Sansinenea Estibaliz;
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Benemerita Univ Autonoma Puebla Fac Ciencias Quim Puebla 72570 Pue Mexico;

Benemerita Univ Autonoma Puebla Fac Ciencias Quim Puebla 72570 Pue Mexico;

Benemerita Univ Autonoma Puebla Fac Ciencias Quim Puebla 72570 Pue Mexico;

Benemerita Univ Autonoma Puebla Fac Ciencias Quim Puebla 72570 Pue Mexico;

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正文语种 eng
中图分类药学;
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study

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