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首页> 外文期刊>The Journal of Antibiotics: An International Journal >The occurrence of antibiotic resistance genes in the microbiota of yak, beef and dairy cattle characterized by a metagenomic approach
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The occurrence of antibiotic resistance genes in the microbiota of yak, beef and dairy cattle characterized by a metagenomic approach

机译：牦牛，牛肉和奶牛微生物菌在抗生素中的发生抗生素抗生素基因的发生

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摘要

Drug resistance has been partly driven by the overuse of antimicrobials in agricultural animal feed. Better understanding of antibiotic resistance in bovine gut is needed to assess its potential effects based on metagenomic approach and analysis. In this study, we collected 40 fecal samples to explore drug resistance derived from antibiotic use in the bacterial community by an analysis of the diversities and differences of antibiotic-resistant genes (ARGs) in the gut microbiota from yak, beef, and dairy cattle. Overall, 1688 genes were annotated, including 734 ARG subtypes. The ARGs were related to tetracyclines, quinolones, beta-lactam, and aminoglycosides, in accordance with the antibiotics widely used in the clinic for humans or animals. The emergence, prevalence, and differences in resistance genes in the intestines of yaks, beef, and dairy cattle may be caused by the selective pressure of different feeding patterns, where yaks were raised without antibiotics for growth promotion. In addition, the abundance of ARGs in yak was lower than in beef and dairy cattle, whereas the abundance of integron, a kind of mobile genetic elements (MGEs) was higher in yaks than those in beef and dairy cattle. Furthermore, the results of this study could provide the basis for a comprehensive profile of various ARGs among yak, beef, and dairy cattle in future.
机译：耐药性的部分原因是在农业动物饲料中过度使用抗菌剂。需要更好地了解牛肠道中的抗生素耐药性，以便基于宏基因组方法和分析评估其潜在影响。在这项研究中，我们收集了40份粪便样本，通过分析牦牛、牛肉和奶牛肠道微生物群中抗生素耐药基因（ARG）的多样性和差异，探索细菌群落中抗生素使用产生的耐药性。总的来说，1688个基因被注释，包括734个ARG亚型。ARG与四环素类、喹诺酮类、β-内酰胺类和氨基糖苷类有关，与临床上广泛用于人类或动物的抗生素一致。牦牛、牛肉和奶牛肠道中抗性基因的出现、流行和差异可能是由不同喂养模式的选择压力造成的，在没有抗生素促进生长的情况下饲养牦牛。此外，牦牛体内的精氨酸含量低于牛肉和奶牛，而牦牛体内的整合子（一种可移动遗传元素，MGEs）含量高于牛肉和奶牛。此外，本研究的结果可以为未来牦牛、牛肉和奶牛中各种ARG的全面分析提供基础。

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    Wang Weiwei; Wei Xiaojuan; Wu Lingyu; Shang Xiaofei; Cheng Fusheng; Li Bing; Zhou Xuzheng; Zhang Jiyu;

  • 作者单位

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

    Key Lab New Anim Drug Project Gansu Prov Lanzhou 730050 Gansu Peoples R China;

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  • 正文语种 eng
  • 中图分类 药学;
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