...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Suspected Adverse Drug Reactions From Corticosteroids: Analysis of Reported Notifications to the Portuguese Pharmacovigilance System
【24h】

Suspected Adverse Drug Reactions From Corticosteroids: Analysis of Reported Notifications to the Portuguese Pharmacovigilance System

机译：涉嫌来自皮质类固醇的不良药物反应：对葡萄牙药物理解系统的报告通知分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We performed a retrospective, observational, and descriptive study on the reports of adverse reactions resulting from the use of corticosteroids, based on data from the Portuguese Pharmacovigilance System recorded between January 2009 and December 20I8.A total of 569 reports with at least I suspected corticosteroid were included in the study, of which 59.1% belonged to individuals aged between 19 and 64 years. There was no significant predominance of sex,with 55% female patients.The notification trend has increased over the years,with the highest number of cases in 2018, 29.5%. Among the 3 groups of health professionals (nurses, pharmacists, and physicians), physicians were the ones who notified the majority. Regarding seriousness, 89.1% were classified as serious, and the most commonly reported corticosteroid as suspected drug was prednisolone, 65.6%. The system organ class group was reported in 37.8% of adverse reactions was infections and infestations. Despite the seriousness of most reports, 42.7% evolved to cure, even though 9.3% of the reports led to the death of patients. The assessment of causality by the regulatory authority was not performed in 84.4% of the reported cases. Although there were enhanced reporting rates of adverse reactions to corticosteroids, active search of their occurrence must be done. In light of the results obtained, educational programs about the importance of pharmacovigilance are essential.
机译：我们根据葡萄牙药物警戒系统2009年1月至2008年12月记录的数据，对使用皮质类固醇引起的不良反应报告进行了回顾性、观察性和描述性研究。研究共包括569份至少有我怀疑使用皮质类固醇的报告，其中59.1%属于19至64岁的人群。没有明显的性别优势，女性患者占55%。近年来，通报趋势有所增加，2018年的病例数最高，为29.5%。在三组卫生专业人员（护士、药剂师和医生）中，医生是通知大多数人的人。关于严重性，89.1%被归类为严重，最常见的可疑药物皮质类固醇是泼尼松龙，占65.6%。据报道，系统器官类别组中37.8%的不良反应是感染和感染。尽管大多数报告的严重性很高，但42.7%的报告进展为治愈，尽管9.3%的报告导致患者死亡。84.4%的报告病例没有进行监管机构的因果关系评估。尽管皮质类固醇不良反应的报告率有所提高，但必须积极调查其发生情况。根据获得的结果，有关药物警戒重要性的教育计划至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号