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首页> 外文期刊>The journal of clinical psychiatry >Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie
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Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie

机译:血液水平优化临床实践中的抗精神病药治疗:Arbeitsgemeinschaft Fur Neuropscharogie und PharmakogsChiaverie的美国临床精神医学和治疗药物监测工作队的联合共识声明

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摘要

Objective: The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use and dosing decisions. The application of TDM for antipsychotics can be helpful in numerous challenging clinical scenarios, such as lack of therapeutic response, relapse, or adverse drug reactions (ADRs) related to antipsychotic treatment. The benefits of TDM may be particularly evident in the treatment of highly vulnerable patient subgroups, such as children, adolescents, pregnant women, and the elderly. The main aim of this article is to aid clinicians who routinely prescribe antipsychotics to successfully apply TDM in routine clinical practice in order to help optimize the efficacy and safety of those antipsychotics.
机译:目的:血液中抗精神病药物水平的量化,也称为治疗药物监测(TDM),是现代个性化治疗的潜在有用工具,可用于增加抗精神病药物的使用和剂量决定。TDM在抗精神病药物中的应用在许多具有挑战性的临床场景中都有帮助,例如缺乏治疗反应、复发或与抗精神病药物治疗相关的药物不良反应(ADR)。TDM的好处可能在治疗高度脆弱的患者亚群时尤其明显,如儿童、青少年、孕妇和老年人。本文的主要目的是帮助常规处方抗精神病药物的临床医生在常规临床实践中成功应用TDM,以帮助优化这些抗精神病药物的疗效和安全性。

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  • 来源
    《The journal of clinical psychiatry》 |2020年第3期|共11页
  • 作者单位

    Northwell Hlth Zucker Hillside Hosp Dept Psychiat Glen Oaks NY 11004 USA;

    Northwell Hlth Zucker Hillside Hosp Dept Psychiat Glen Oaks NY 11004 USA;

    Northwell Hlth Zucker Hillside Hosp Dept Psychiat Glen Oaks NY 11004 USA;

    Univ Calif Los Angeles David Geffen Sch Med Psychiat &

    Biobehav Sci Los Angeles CA 90095 USA;

    New York Med Coll Dept Psychiat &

    Behav Sci Valhalla NY 10595 USA;

    Thriving Mind South Florida Behav Hlth Network Miami FL USA;

    Northwell Hlth Zucker Hillside Hosp Dept Psychiat Glen Oaks NY 11004 USA;

    NYU Langone Med Ctr Dept Psychiat New York NY USA;

    Univ Maryland Sch Med Dept Psychiat Baltimore MD 21201 USA;

    Harvard Med Sch Massachusetts Gen Hosp Dept Psychiat Boston MA 02115 USA;

    NIAAA Sect Clin Psychoneuroendocrinol &

    Neuropsychophar Div Intramural Clin &

    Biol Res Bethesda;

    Alexianer Hosp Aachen Aachen Germany;

    Serv Psichiatr Comprensorio Sanit Bolzano Bolzano Italy;

    Med Univ Innsbruck Dept Psychiat &

    Psychotherapy Expt Psychiat Unit Innsbruck Austria;

    Univ Regensburg Clin Pharmacol Dept Psychiat &

    Psychotherapy Regensburg Germany;

    Univ Lausanne Dept Psychiat Prilly Switzerland;

    Univ Med Ctr Mainz Dept Psychiat &

    Psychotherapy Mainz Germany;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Mol Neuroimaging Mannheim Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 精神病学;
  • 关键词

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