Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine.

de Lucena D; Fernandes BS; Kunz

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Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine.

机译：血清脑衍生的神经营养因子水平之间缺乏关联，在一双盲，随机，安慰剂对照试验中缺乏精神分裂症症状，作为氯氮平的辅助治疗。

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To the Editor: We have shown that memantine as adjunctive therapy to clozapine improves negative and positive symptoms in patients with refractory schizophrenia.1 However, the biologic mechanism for this improvement remains unclear. Meisner et al2 have reported an interaction between memantine and brain-derived neurotrophic factor (BDNF). An effect of memantine on nonneuronal BDNF-producing cells may explain this interaction by activation of extrasynaptic N-methyl-D-aspartate receptors and promotion of neuronal functioning. BDNF is implicated in many psychiatric disorders, such as schizophrenia.

机译：编辑：我们已经证明，美金刚作为氯氮平的辅助治疗可以改善难治性精神分裂症患者的阴性和阳性症状。1然而，这种改善的生物学机制尚不清楚。Meisner等人报道了美金刚和脑源性神经营养因子（BDNF）之间的相互作用。美金刚对非神经性BDNF产生细胞的作用可能通过激活突触外N-甲基-D-天冬氨酸受体和促进神经元功能来解释这种相互作用。BDNF与许多精神疾病有关，如精神分裂症。

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《The journal of clinical psychiatry》 |2010年第1期|共2页
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de Lucena D; Fernandes BS; Kunz;
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机译：在美金刚作为氯氮平辅助治疗的双盲，随机，安慰剂对照试验中，血清脑源性神经营养因子水平与精神分裂症症状改善之间缺乏关联。
6. Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine. [J] . de Lucena D, Fernandes BS, Kunz The journal of clinical psychiatry . 2010,第1期

机译：血清脑衍生的神经营养因子水平之间缺乏关联，在一双盲，随机，安慰剂对照试验中缺乏精神分裂症症状，作为氯氮平的辅助治疗。
7. Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine. [J] . de Lucena D, Fernandes BS, Kunz The journal of clinical psychiatry . 2010,第1期

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Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine.

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