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首页> 外文期刊>The Journal of dermatology >Subcutaneous phaeohyphomycosis due toExophiala jeanselmeifollowing renal transplantation: A case report with a published work review of phaeohyphomycosis in Japan
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Subcutaneous phaeohyphomycosis due toExophiala jeanselmeifollowing renal transplantation: A case report with a published work review of phaeohyphomycosis in Japan

机译：肾移植肾移植的皮下氏植物骨髓病

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摘要

We describe a case of cutaneous phaeohyphomycosis following renal transplantation and include a review of the previously published Japanese cases. A 40-year-old Japanese woman taking immunosuppressants following renal transplantation 6 years prior presented to our hospital with a subcutaneous lesion on her right leg. Skin biopsy revealed an abscess, and culture confirmedExophiala jeanselmeito be the causative agent. Treatment with itraconazole combined with surgical drainage was effective, and the lesion disappeared after 15 months. Upon review of 128 Japanese phaeohyphomycosis cases, it was found that more than 80% of the cases occurred in patients aged more than 60 years, and most cases involved underlying diseases associated with immunodeficiency.E. jeanselmeiwas the most common etiologic fungus. Recently, however, theExophialaspecies has been reclassified based on molecular identification, and cases due toE. jeanselmeidecreased with the concomitant increase of cases due toExophialaoligospermaandExophialaxenobiotica. In approximately half of the cases, lesions were treated by surgical removal, with or without concomitant antifungal drugs. Itraconazole was the antifungal agent most frequently used. In many cases, the disease course was reported as either healing or improving. There was no difference in either treatment or prognosis based on the etiologic species of fungus.
机译：我们描述了一例肾移植后皮肤暗色丝孢菌病，并回顾了之前发表的日本病例。一名40岁的日本女性在肾移植6年前服用免疫抑制剂后，右腿出现皮下病变。皮肤活检显示一个脓肿，培养证实jeanselmeito是病原体。伊曲康唑联合手术引流治疗有效，15个月后病灶消失。通过对128例日本暗色丝孢菌病病例的回顾，发现80%以上的病例发生在60岁以上的患者身上，大多数病例涉及与免疫缺陷相关的潜在疾病。E.Jeanselmewa是最常见的病原真菌。然而，最近，根据分子鉴定和因toE引起的病例，嗜热菌已被重新分类。Jeanselmed随着因嗜酸寡精症和嗜酸异源生物引起的病例的增加而增加。在大约一半的病例中，病变通过手术切除进行治疗，同时使用或不使用抗真菌药物。伊曲康唑是最常用的抗真菌药物。在许多情况下，疾病过程被报告为愈合或好转。根据真菌的病原种类，治疗或预后没有差异。

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