Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

Furue Kazuhisa; Ulzii Dugarmaa; Tanaka Yuka; Ito Takamichi; Tsuji Gaku; Kido-Nakahara Makiko; Nakahara Takeshi; Furue Masutaka

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Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

机译：牛皮癣和特应性皮炎中表皮刮伤损伤的致病意义

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Mechanical scratching, a common external stress affecting the skin, is induced by various causes, such as pruritus. Scratch injury to epidermal keratinocytes upregulates the production and release of chemokine (C-C motif) ligand 20 (CCL20)in vitro, which selectively chemoattracts interleukin (IL)-17A-producing immune cells that express chemokine (C-C motif) receptor 6 (CCR6). In IL-17A-dominant psoriasis, scratch-induced CCL20 upregulation and subsequent accumulation of IL-17A-producing immune cells and CCR6(+)mature dendritic cells may trigger the development of psoriatic lesions, a process known as the Koebner phenomenon. In IL-4/IL-13-dominant atopic dermatitis, pruritus and subsequent scratching are the primary symptoms. Scratch-induced CCL20 production from keratinocytes may explain why IL-17A levels are also elevated in atopic dermatitis. In contrast, mechanical scratching is likely to negatively regulate IL-13 signaling by upregulating the expression of IL-13 receptor alpha 2, which serves as a decoy receptor for IL-13 in keratinocytes. In this review, we summarize current reports on topics related to the pathogenic role of epidermal scratch injury in psoriasis and atopic dermatitis.

机译：机械性抓挠是一种影响皮肤的常见外部应力，由各种原因引起，如瘙痒。表皮角质形成细胞划痕损伤可在体外上调趋化因子（C-C基序）配体20（CCL20）的产生和释放，该配体选择性地吸引产生白细胞介素（IL）-17A的免疫细胞，这些细胞表达趋化因子（C-C基序）受体6（CCR6）。在以IL-17A为主的银屑病中，划痕诱导的CCL20上调以及随后产生IL-17A的免疫细胞和CCR6（+）成熟树突状细胞的积聚可能触发银屑病病变的发展，这一过程被称为Koebner现象。在以IL-4/IL-13为主的特应性皮炎中，瘙痒和随后的抓挠是主要症状。划痕诱导角质形成细胞产生CCL20可能解释了为什么IL-17A水平在特应性皮炎中也升高。相比之下，机械抓挠可能通过上调IL-13受体α2的表达来负向调节IL-13信号，后者在角质形成细胞中充当IL-13的诱饵受体。在这篇综述中，我们总结了当前关于表皮划痕损伤在银屑病和特应性皮炎中的致病作用的报道。

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来源
《The Journal of dermatology》 |2020年第9期|共10页
作者
Furue Kazuhisa; Ulzii Dugarmaa; Tanaka Yuka; Ito Takamichi; Tsuji Gaku; Kido-Nakahara Makiko; Nakahara Takeshi; Furue Masutaka;
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作者单位

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

Kyushu Univ Grad Sch Med Sci Dept Dermatol Fukuoka Japan;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
关键词
atopic dermatitis; chemokine (C-C motif) ligand 20; interleukin-13 receptor alpha 2; psoriasis; scratch injury;

机译：特应激性皮炎;趋化因子（C-C泳学）配体20;白细胞介素-13受体α2;牛皮癣;划伤伤害;

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1. PHENOTYPIC CHARACTERISTICS OF HUMAN BLOOD MONOCYTE SUBPOPULATIONS IN PSORIASIS AND ATOPIC DERMATITIS: EVIDENCE FOR DIFFERENTIAL EXPRESSION OF SURFACE MOLECULES [J] . M Zheng, U Mrowietz, E Christophers 中华医学杂志：英文版 . 1995,第003期
2. Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis [J] . Ping Liu, Yan Zhao, Zhang-Lei Mu, 中华医学杂志（英文版） . 2016,第007期
3. Concomitant atopic dermatitis and narcolepsy type 1:psychiatric implications and challenges in management [J] . Justin Chin, Craig Bearison, Nanette Silverberg, 综合精神医学（英文） . 2019,第005期
4. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis [J] . Cristina de Guzman Strong, Sean Conlan, Clayton B. Deming, Human Molecular Genetics . 2010,第8期

机译：表皮分化复合物突触阻滞中的调节元件环境：对特应性皮炎和牛皮癣的影响
5. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. [J] . de Guzman Strong C, Conlan S, Deming CB, Human Molecular Genetics . 2010,第8期

机译：表皮分化复合物突触阻滞中的调节元件环境：对特应性皮炎和牛皮癣的影响。
6. JAK1/3-inhibition preserves epidermal morphology in full thickness 3D skin models of atopic dermatitis and psoriasis [J] . Clarysse K., Pfaff C. M., Marquardt Y., Experimental dermatology . 2019,第3期

机译：JAK1 / 3抑制保留了特应性皮炎和牛皮癣的全厚3D皮肤模型中表皮形态
7. Differentiating Atopic Dermatitis and Psoriasis Chronic Plaque using Convolutional Neural Network MobileNet Architecture [C] . Dionis Padilla, Analyn Yumang, Airish Laine Diaz, International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management . 2019

机译：使用卷积神经网络MobileNet架构区分特应性皮炎和牛皮癣慢性斑块
8. Investigating the Role of the Human Microbiome in the Pathogenesis of AtopicDermatitis in the Mechanisms of the Progression of Atopic Dermatitis to Asthmain Children (MPAACH) Cohort [D] . Gonzalez, Tammy. 2020

机译：调查人微生物组在特应性皮炎进展到哮喘儿童（MPAACH）队列进展的机制中的作用
9. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis [O] . Cristina de Guzman Strong, Sean Conlan, Clayton B. Deming, -1

机译：表皮分化复合物突触阻滞中的调节元件环境：对特应性皮炎和牛皮癣的影响
10. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis [O] . de Guzman Strong, Cristina, Conlan, Sean, Deming, Clayton B., 2010

机译：表皮分化复合物突触阻滞中的调节元件环境：对特应性皮炎和牛皮癣的影响
11. 'Staphylococcus aureus' and the Microbial Ecology of Atopic Dermatitis. [R] . Bibel, D. J., Greenberg, J. H., Cook, J. L. 1977

机译：'金黄色葡萄球菌'和特应性皮炎的微生物生态学。

Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

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