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首页> 外文期刊>The Annals of otology, rhinology, and laryngology >Detection of Pepsin in Oral Secretions of Infants with and without Laryngomalacia
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Detection of Pepsin in Oral Secretions of Infants with and without Laryngomalacia

机译：用喉头癌症的婴儿口腔分泌物中的胃蛋白酶检测

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Objectives: Laryngomalacia is a common cause of stridor in infants and is associated with laryngopharyngeal reflux (LPR). Although pepsin in operative supraglottic lavage specimens is associated with severe laryngomalacia, detection of pepsin in oral secretions has not been demonstrated in an outpatient setting. Methods: Children <2 years old with laryngomalacia diagnosed by flexible laryngoscopy and children without stridor were selected. Oral secretion samples were obtained in clinic from all subjects. Pepsin, IL-1 beta, and IL-8 enzyme-linked immunosorbent assays were performed to determine presence of LPR. Results: Sixteen laryngomalacia and sixteen controls were enrolled. Pepsin was detected more frequently in oral secretions of patients with laryngomalacia (13/16) than in controls (2/16; P < .001). Four patients with laryngomalacia developed symptoms requiring supraglottoplasty. Presence and level of salivary pepsin was not significantly associated with need for surgical management, nor were the levels or presence of IL-1 beta or IL-8 significantly associated with presence or level of pepsin, diagnosis of laryngomalacia, or need for operative management. Conclusion: Pepsin in saliva appears to be associated with laryngomalacia, suggesting a role for salivary pepsin as a noninvasive marker of LPR in patients with laryngomalacia. Future studies will determine the utility of this test in laryngomalacia.
机译：目的：喉软化症是婴儿喘鸣的常见原因，与咽喉反流（LPR）有关。虽然手术声门上灌洗标本中的胃蛋白酶与严重喉软化症有关，但在门诊环境中尚未发现口腔分泌物中的胃蛋白酶。方法：选择经软喉镜诊断为喉软化症的2岁以下儿童和无喘鸣音的儿童。所有受试者的口腔分泌物样本均在临床上获得。进行胃蛋白酶、IL-1β和IL-8酶联免疫吸附试验以确定LPR的存在。结果：纳入16例喉软化症患者和16例对照组。胃蛋白酶在喉软化症患者（13/16）的口腔分泌物中的检出率高于对照组（2/16；P<0.001）。四名喉阿拉西亚患者出现需要声门上成形术的症状。唾液胃蛋白酶的存在和水平与手术治疗的需要没有显著相关性，IL-1β或IL-8的水平或存在与胃蛋白酶的存在或水平、喉软化症的诊断或手术治疗的需要也没有显著相关性。结论：唾液中的胃蛋白酶似乎与喉软化症有关，提示唾液胃蛋白酶在喉软化症患者中作为LPR的无创性标志物发挥作用。未来的研究将确定这种测试在喉盲症中的实用性。

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