• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Evaluation of Warfarin Use in Patients With Mental Health Conditions in a Rural Community Health Center System
【24h】

Evaluation of Warfarin Use in Patients With Mental Health Conditions in a Rural Community Health Center System

机译：农村社区卫生中心系统心理健康状况患者的旱法用法评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Mental health conditions (MHCs) may affect a patient’s ability to comply with requirements necessary for safe warfarin use. Objective: To describe warfarin control, defined as time in therapeutic range (TTR), for patients with and without MHCs receiving care through a pharmacist-driven anticoagulation service within a rural community health center system. Methods: Retrospective cohort study of patients on warfarin between January 1, 2014, and December 31, 2017. The primary study endpoint was TTR. Secondary endpoints were the number of international normalized ratios (INRs) per 30 days, percentage of INRs within, above, and below target range, and warfarin-related adverse events. Results: A total of 79 patients were included—37 with and 42 without MHCs. Patients were mostly male (n = 47; 59.5%) and prescribed warfarin for atrial fibrillation (n = 45; 57.0%). There were no differences in overall TTR between those with (59.6%; interquartile range = 41.8-73.4) versus without (63.4%; interquartile range = 46.7-73.6) MHCs ( P = .542). Secondary outcomes showed no differences in the frequency or percentage of INRs in, above, or below target range (all P > .05). However, there were about twice as many hemorrhagic complications in the group with MHCs (27% vs 11.9%; P = .149). Conclusion: Patients with MHCs experienced no difference in overall TTR as compared to patients without MHCs. However, there was a non-statistically significant reduction in TTR, which would be consistent with limited existing data and demonstrates possible reproducibility to a rural, underserved patient population. Future research is needed to validate these outcomes.
机译：背景：心理健康状况（MHC）可能会影响患者遵守安全使用华法林所需要求的能力。目的：描述在农村社区卫生中心系统内通过药剂师驱动的抗凝服务接受治疗的MHC患者和非MHC患者的华法林控制（定义为治疗范围内的时间（TTR））。方法：对2014年1月1日至2017年12月31日期间服用华法林的患者进行回顾性队列研究。主要研究终点为TTR。次要终点是每30天国际标准化比率（INR）的数量、INR在目标范围内、高于目标范围和低于目标范围的百分比，以及华法林相关的不良事件。结果：共纳入79例患者，其中37例有MHC，42例无MHC。患者大多为男性（n=47；59.5%），房颤患者服用华法林（n=45；57.0%）。有（59.6%；四分位区间=41.8-73.4）MHC组与无（63.4%；四分位区间=46.7-73.6）MHC组之间的总体TTR无差异（P=0.542）。次要结果显示INR的频率或百分比在目标范围之内、之上或之下没有差异（均P>0.05）。然而，MHC组的出血性并发症大约是MHC组的两倍（分别为27%和11.9%；P=0.149）。结论：与无MHC的患者相比，MHC患者的总体TTR没有差异。然而，TTR的降低在统计学上并不显著，这与有限的现有数据一致，并证明对农村、服务不足的患者群体可能具有重现性。未来的研究需要验证这些结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号