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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Assessing the Quality of Life in Patients With Polyarthralgia Based on 25-Hydroxycholecalciferol Levels
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Assessing the Quality of Life in Patients With Polyarthralgia Based on 25-Hydroxycholecalciferol Levels

机译：基于25-羟基胆嘧啶水平评估多甲基痛患者的生活质量

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Background Vitamin D deficiency is widespread, yet it is the most underdiagnosed and undertreated nutritional deficiency and has a very crucial clinical importance in today's medical field. Objective To assess quality of life in patients with polyarthralgia based on 25-hydroxycholecalciferol (25-(OH)D) levels, which will help understand the importance of vitamin D in a broader sense. Methodology Our panel study was carried out in the department of orthopedics of a tertiary care hospital in southern India between October 1, 2018, and February 28, 2019. A total of 114 patients with polyarthralgia from the outpatient department were included in the study. Results In our study, there was a predominance of female patients (77.2%). Overall, 92.10% of our study population were aged between 21 and 60 years. The highest percentage of low vitamin D status was detected in unexplained polyarthralgia cases (52.63%), who did not have any comorbid condition except a low serum level of 25-(OH)D level. There was a strong association between quality of life, before and after supplementation of vitamin D (P< .0001), for every domain of the36-item Short Form Survey. Conclusion The36-item Short Form Survey analysis showed that the patients with polyarthralgia whose serum level of 25-(OH)D was found below the optimal range had dramatic improvement in their symptoms after vitamin D supplementation. Based on the findings of our study, we strongly recommend screening for vitamin D deficiency in those who are at risk, as features of low vitamin D are mostly reversible with proper supplementation.
机译：背景：维生素D缺乏症是一种普遍存在的营养缺乏症，但它是最未得到充分诊断和治疗的营养缺乏症，在当今医学领域具有非常重要的临床意义。目的基于25-羟基胆钙化醇（25-（OH）D）水平评估多关节痛患者的生活质量，这将有助于从更广泛的意义上理解维生素D的重要性。方法：我们的小组研究于2018年10月1日至2019年2月28日在印度南部一家三级医院的骨科进行。共有114名门诊多关节痛患者被纳入研究。结果在我们的研究中，女性患者占优势（77.2%）。总体而言，92.10%的研究人群年龄在21至60岁之间。在原因不明的多关节痛患者（52.63%）中，维生素D水平低下的比例最高，这些患者除血清25-（OH）D水平较低外，没有任何合并症。在36项简式调查的每个领域中，补充维生素D前后的生活质量都有很强的相关性（P<0.0001）。结论36项简表调查分析显示，补充维生素D后，血清25-（OH）D水平低于最佳范围的多关节痛患者的症状有显著改善。根据我们的研究结果，我们强烈建议高危人群筛查维生素D缺乏症，因为低维生素D的特征在适当补充后基本上是可逆的。

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