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首页> 外文期刊>The Journal of Nutritional Biochemistry >Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice
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Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

机译：饮食诱导的植入血液上各种协作杂交鼠标创始人菌株揭示了129S1 / SVIMJ，PWK / EIJ，CAST / PHJ和WSB / EIJ小鼠的槲皮素治疗的不同表型反应和改善

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Significant evidence suggests protective effects of flavonoids against obesity in animal models, but these often do not translate to humans. One explanation for this disconnect is use of a few mouse strains (notably C57BL/6 J) in obesity studies. Obesity is a multifactorial disease. The underlying causes are not fully replicated by the high-fat C57BL/6 J model, despite phenotypic similarities. Furthermore, the impact of genetic factors on the activities flavonoids is unknown. This study was designed to explore how diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid. A subset of Collaborative Cross founder strains (males and females) were placed on dietary treatments (low-fat, high-fat, high-fat with quercetin, high-fat with quercetin and antibiotics) longitudinally. Diverse responses were observed across strains and sexes. Quercetin appeared to moderately blunt weight gain in male C57 and both sexes of 129S1/SvImJ mice, and slightly increased weight gain in female C57 mice. Surprisingly, quercetin dramatically blunted weight gain in male, but not female, PWK/PhJ mice. For female mice, quercetin blunted weight gain (relative to the high-fat phase) in CAST/PhJ, PWK/EiJ and WSB/EiJ mice compared to C57. Antibiotics did not generally result in loss of protective effects of quercetin. This highlights complex interactions tween genetic factors, sex, obesity stimuli, and flavonoid intake, and the need to move away from single inbred mouse models to enhance translatability diverse humans. These data justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools the field of personalized nutrition. (C) 2020 Elsevier Inc. All rights reserved.
机译：大量证据表明类黄酮对动物模型中的肥胖有保护作用，但这些作用通常不会转化为人类。这种脱节的一个解释是在肥胖研究中使用了一些小鼠品系（尤其是C57BL/6 J）。肥胖是一种多因素疾病。尽管表型相似，但高脂C57BL/6 J模型并未完全复制根本原因。此外，遗传因素对黄酮类化合物活性的影响尚不清楚。这项研究旨在探索当喂食具有代表性的类黄酮时，不同的小鼠品系对饮食诱导的肥胖的反应。将协作交叉创始人菌株（男性和女性）的子集纵向放置在饮食治疗（低脂、高脂、含槲皮素的高脂、含槲皮素和抗生素的高脂）上。在不同的菌株和性别中观察到了不同的反应。槲皮素对雄性C57小鼠和129S1/SvImJ小鼠的体重增加似乎有一定的抑制作用，而雌性C57小鼠的体重增加则略有增加。令人惊讶的是，槲皮素显著减缓了PWK/PhJ小鼠雄性（而非雌性）的体重增加。对于雌性小鼠，与C57相比，槲皮素减缓了CAST/PhJ、PWK/EiJ和WSB/EiJ小鼠的体重增加（相对于高脂肪期）。抗生素通常不会导致槲皮素保护作用的丧失。这突出了遗传因素、性别、肥胖刺激物和类黄酮摄入之间的复杂相互作用，以及摆脱单一近交系小鼠模型以增强人类多样性的必要性。这些数据证明了使用基因多样性合作杂交和多样性远交模型的合理性，这些模型正在成为个性化营养领域的宝贵工具。（C） 2020爱思唯尔公司版权所有。

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