Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

Iglesias-Carres Lisard; Hughes Michael D.; Steele Cortney N.; Ponder Monica A.; Davy Kevin P.; Neilson Andrew P.

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Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

机译：使用膳食植物化学物质抑制三甲胺N-氧化物形成

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Trimethylamine-N-oxide (TMAO) has been reported as a risk factor for atherosclerosis development, as well as for other cardiovascular disease (CVD) pathologies. The objective of this review is to provide a useful summary on the use of phytochemicals as TMAO-reducing agents. This review discusses the main mechanisms by which TMAO promotes CVD, including the modulation of lipid and bile acid metabolism, and the promotion of endothelial dysfunction and oxidative stress. Current knowledge on the available strategies to reduce TMAO formation are discussed, highlighting the effect and potential of phytochemicals. Overall, phytochemicals (i.e., phenolic compounds or glucosinolates) reduce TMAO formation by modulating gut microbiota composition and/or function, inhibiting host?s capacity to metabolize TMA to TMAO, or a combination of both. Perspectives for design of future studies involving phytochemicals as TMAO-reducing agents are discussed. Overall, the information provided by this review outlines the current state of the art of the role of phytochemicals as TMAO reducing agents, providing valuable insight to further advance in this field of study. ? 2021 Elsevier Inc. All rights reserved.

机译：三甲胺-N-氧化物（TMAO）已被报道为动脉粥样硬化发展的危险因素，以及其他心血管疾病（CVD）病理学的危险因素。本综述的目的是对植物化学物质作为TMAO还原剂的使用提供有用的总结。本文综述了TMAO促进CVD的主要机制，包括调节脂质和胆汁酸代谢，促进内皮功能障碍和氧化应激。讨论了减少TMAO形成的现有策略，强调了植物化学物质的作用和潜力。总的来说，植物化学物质（即酚类化合物或硫代葡萄糖苷）通过调节肠道微生物群的组成和/或功能，抑制宿主？s将TMA代谢为TMAO的能力，或两者的结合。展望未来的研究涉及植物化学物质作为TMAO还原剂的设计进行了讨论。总的来说，本综述提供的信息概述了植物化学物质作为TMAO还原剂作用的最新进展，为该研究领域的进一步进展提供了宝贵的见解？2021爱思唯尔公司保留所有权利。

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来源
《The Journal of Nutritional Biochemistry》 |2021年第1期|共17页
作者
Iglesias-Carres Lisard; Hughes Michael D.; Steele Cortney N.; Ponder Monica A.; Davy Kevin P.; Neilson Andrew P.;
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作者单位

North Carolina State Univ Plants Human Hlth Inst Dept Food Bioproc &

Nutr Sci 600 Laureate Way Kannapolis NC 28081 USA;

Virginia Polytech Inst &

State Univ Dept Food Sci &

Technol Blacksburg VA 24061 USA;

Virginia Polytech Inst &

State Univ Dept Human Nutr Foods &

Exercise Blacksburg VA USA;

Virginia Polytech Inst &

State Univ Dept Food Sci &

Technol Blacksburg VA 24061 USA;

Virginia Polytech Inst &

State Univ Dept Human Nutr Foods &

Exercise Blacksburg VA USA;

North Carolina State Univ Plants Human Hlth Inst Dept Food Bioproc &

Nutr Sci 600 Laureate Way Kannapolis NC 28081 USA;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Atherosclerosis; Cardiovasculardisease; Phytochemicals; TMAO;

机译：动脉粥样硬化;心肌诱导酶;植物化学物质;tmao;

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2. Contribution of trimethylamine N-oxide on the growth and pressure tolerance of deep-sea bacteria [J] . YIN Qunjian, ZHANG Weijia, LI Xuegong, 中国海洋湖沼学报（英文版） . 2019,第001期
3. Contribution of trimethylamine N-oxide on the growth and pressure tolerance of deep-sea bacteria [J] . YIN Qunjian, ZHANG Weijia, LI Xuegong, 海洋湖沼学报（英文） . 2019,第001期
4. Enhancing Effect of Fe2＋ on the Formaldehyde Production from Trimethylamine N-oxide Decomposition Catalyzed by the Extract ofHarpadon nehereus Kidney [J] . SUN Yong, ZHOU Deqing, ZHAO Feng 中国海洋大学学报：英文版 . 2011,第001期
5. Inhibition of amyloid fibril formation of hen egg white lysozyme by trimethylamine N-oxide at low pH [J] . Jaros?aw Wawer, Joanna Krakowiak, Micha? Szociński, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2014,第Null期

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6. Dietary Trimethylamine N-Oxide Exacerbated Atherosclerosis under a Low-Fat Rather than High-Fat Diet [J] . Yu Zhu-Lin, Ding Lin, Xue Chang-Hu, Journal of Agricultural and Food Chemistry . 2020,第25期

机译：膳食三甲胺N-氧化物在低脂肪而不是高脂饮食下恶化动脉粥样硬化
7. Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women [J] . Wang Zeneng, Bergeron Nathalie, Levison Bruce S., European Heart Journal: The Journal of the European Society of Cardiology . 2019,第7期

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Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

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