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首页> 外文期刊>The Journal of Nutritional Biochemistry >Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases
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Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

机译：白藜芦醇在神经变性疾病中抑制神经引起的信号传导机制

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摘要

Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), and Parkinson's disease (PD), are characterized by the progressive loss of the structure and function of neurons and most commonly occur in the elderly population. Microglia are resident macrophages of the central nervous system (CNS). The neuroinflammation caused by excessive microglial activation is closely related to the onset and progression of many NDs. Therefore, inhibiting excessive microglial activation is a potential drug target for controlling neuroinflammation. In recent years, natural products as modulators of microglial polarization have attracted considerable attention in the field of NDs therapy. Furthermore, resveratrol (RES) has been found to have a protective effect in NDs through the inhibition of microglial activation and the regulation of neuroinflammation. In this review, we mainly summarize the therapeutic potential of RES and its various molecular mechanisms in the treatment of NDs through the modulation of microglial activation. (c) 2020 Elsevier Inc. All rights reserved.
机译：包括阿尔茨海默病（AD）和帕金森病（PD）在内的神经退行性疾病（NDs）以神经元结构和功能的逐渐丧失为特征，最常见于老年人群。小胶质细胞是中枢神经系统（CNS）的常驻巨噬细胞。小胶质细胞过度激活引起的神经炎症与许多NDs的发生和发展密切相关。因此，抑制小胶质细胞过度激活是控制神经炎症的潜在药物靶点。近年来，天然产物作为小胶质细胞极化的调节剂在NDs治疗领域引起了广泛关注。此外，白藜芦醇（resveratrol，RES）通过抑制小胶质细胞的激活和调节神经炎症，对NDs具有保护作用。在这篇综述中，我们主要总结了RES的治疗潜力及其通过调节小胶质细胞激活治疗NDs的各种分子机制。（c） 2020爱思唯尔公司版权所有。

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  • 作者

    Huang Juan; Huang Nanqu; Xu Shangfu; Luo Yong; Li Yan; Jin Hai; Yu Changyin; Shi Jingshan; Jin Feng;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Inst Med Sci Dept Pharmacol &

    Chem Biol Shanghai Peoples R China;

    Zunyi Med Univ Peoples Hosp Zunyi 1 Affiliated Hosp 3 Drug Clin Trial Inst Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Key Lab Basic Pharmacol Minist Educ Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Peoples Hosp Zunyi 1 Affiliated Hosp 3 Drug Clin Trial Inst Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Sch Publ Hlth Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Affiliated Hosp Inst Digest Dis Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Affiliated Hosp Dept Neurol Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Key Lab Basic Pharmacol Minist Educ Zunyi Guizhou Peoples R China;

    Zunyi Med Univ Key Lab Basic Pharmacol Minist Educ Zunyi Guizhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Resveratrol; Microglia; Neuroinflammation; Neurodegenerative diseases; Central nervous system;

    机译：白藜芦醇;小胶质细胞;神经源性;神经变性疾病;中枢神经系统;

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