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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effect of resveratrol on behavioral, biochemical, and immunological parameters of DBA/2J and tetrahybrid DBCB mice receiving diet with excess fat and fructose
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Effect of resveratrol on behavioral, biochemical, and immunological parameters of DBA/2J and tetrahybrid DBCB mice receiving diet with excess fat and fructose

机译：白藜芦醇对DBA / 2J的行为，生化和免疫参数的影响，所述DBA / 2J和Tetrahybrid DBCB小鼠接受多余脂肪和果糖的饮食

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摘要

Polyphenolic biologically active substances (BAS) including resveratrol (R) can exert beneficial effects on fat accumulation, blood pressure, glycemia, insulin sensitivity, and plasma lipid profile in patients with obesity, and associated diseases. The study aimed to determine the effect of R at a dose of 25 mg/kg body weight on the DBA/2J and DBCB mice with diet-induced obesity followed by the consumption high-fat high-carbohydrate diet (HFCD). Behavioral reactions (elevated plus maze [EPM]) and muscle tone (the strength of the forepaw grip) were tested, and plasma biochemical and immunological parameters were assessed. In the repeated EPM test, anxiety increased only in DBCB mice during the second trial. In DBCB mice treated with HFCD, the muscle tone decreased with the second trial; however, this effect was not observed in the background of R consumption. R decreased the level of triglycerides, diminished the activities of alanine and asparagine aminotransferases, which were elevated upon HFCD consumption. Ghrelin level increased after R consumption in mice of both genotypes. The leptin to ghrelin ratio was reduced in DBCB mice receiving R. Consumption of R increased IL-3 and IL-10 levels in both DBA/2J and DBCB mice. IL-12p70 level increased in DBCB mice in response to R. R addition to HFCD reduced several symptoms of dyslipidemia in highly sensitive tetrahybrid mice. The results obtained indicate the importance of a personalized (depending on the genotype) approach when any R prescription, among other BAS and dietary factors, are used in diet therapy for patients with low, moderate and high-risk obesity. (C) 2020 Elsevier Inc. All rights reserved.
机译：包括白藜芦醇（R）在内的多酚生物活性物质（BAS）可以对肥胖和相关疾病患者的脂肪积累、血压、血糖、胰岛素敏感性和血脂谱产生有益影响。本研究旨在确定25 mg/kg体重的R对饮食诱导肥胖的DBA/2J和DBCB小鼠的影响，然后是高脂高碳水化合物饮食（HFCD）。测试行为反应（高架+迷宫[EPM]）和肌肉张力（前爪握力），并评估血浆生化和免疫学参数。在重复的EPM试验中，只有DBCB小鼠在第二次试验中焦虑增加。在用HFCD治疗的DBCB小鼠中，随着第二次试验的进行，肌肉张力降低；然而，在R消耗的背景下没有观察到这种效应。R降低甘油三酯水平，降低丙氨酸和天冬酰胺转氨酶的活性，这些酶在食用HFCD后升高。在两种基因型的小鼠中，服用R后，Ghrelin水平升高。在接受R的DBCB小鼠中，瘦素与ghrelin的比率降低。在DBA/2J和DBCB小鼠中，R的摄入均增加了IL-3和IL-10水平。DBCB小鼠的IL-12p70水平因R的应答而升高。在高度敏感的四倍体小鼠中，添加HFCD可减少几种血脂异常症状。获得的结果表明，当任何R处方以及其他BAS和饮食因素用于低、中、高危肥胖患者的饮食治疗时，个性化（取决于基因型）方法的重要性。（C） 2020爱思唯尔公司版权所有。

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