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首页> 外文期刊>The Journal of Prosthetic Dentistry >Cytotoxic potential of denture base and reline acrylic resins after immersion in disinfectant solutions
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Cytotoxic potential of denture base and reline acrylic resins after immersion in disinfectant solutions

机译：伪造碱的细胞毒性潜力和浸入消毒液中后的丙烯酸树脂

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Statement of problemThe daily immersion of dentures in disinfectant solutions can cause the incorporation of toxic substances in the acrylic resins, and studies evaluating the cumulative effect of disinfectant solutions on cell culture are lacking. PurposeThe purpose of this in?vitro study was to evaluate the cytotoxic potential of cell cultures of denture base and reline acrylic resins after immersion in disinfectant solutions. Material and methodsDisk-shaped specimens (14×1.2 mm) were obtained and divided into groups (n=9) according to the disinfectant solutions (distilled water [control], 2% chlorhexidine digluconate, 3.8% sodium perborate, 0.5% sodium hypochlorite, and apple vinegar) and to the storage period (0, 1, 3, and 6 months). Solutions were changed daily. After the different storage periods, specimens were immersed in culture medium for 24 hours, and extracts were obtained. Human keratinocytes were cultivated, and the cellular metabolism was evaluated by using Alamar Blue. Data were submitted to 3-way analysis of variance and Games-Howell post hoc tests (α=.05). ResultsBoth of the acrylic resins tested showed similar biocompatibility properties after immersion in different solutions (P=.400). Immersion in distilled water, 3.8% sodium perborate, and 0.5% sodium hypochlorite did not affect the cellular metabolism of the keratinocytes (P>.05), regardless of the immersion period and the type of acrylic resin (P>.05). Immersion in 2% chlorhexidine digluconate or apple vinegar resulted in high cytotoxicity over time, until the third month (P .05). ConclusionsThe type of acrylic resin (base or reline) had no significant effect on the viability of cells. Vinegar and chlorhexidine digluconate solutions increased in cytotoxic effect over time, and were strongly cytotoxic after 6 months of immersion. Sodium perborate and sodium hypochlorite were noncytotoxic in all periods of time tested.
机译：问题陈述：假牙每天浸泡在消毒液中可能会导致丙烯酸树脂中含有有毒物质，目前还缺乏评估消毒液对细胞培养累积效应的研究。目的这件事的目的是什么？体外研究旨在评估义齿基托和衬板丙烯酸树脂细胞培养物浸泡在消毒剂溶液中后的细胞毒性潜力。材料和方法获得盘状标本（14×1.2mm），并根据消毒剂溶液（蒸馏水[对照组]、2%二葡萄糖酸氯己定、3.8%过硼酸钠、0.5%次氯酸钠和苹果醋）和储存期（0、1、3和6个月）分为组（n=9）。解决方案每天都在改变。在不同的保存期后，将标本浸泡在培养基中24小时，获得提取物。培养人角质形成细胞，用阿拉玛蓝评价细胞代谢。数据提交给三因素方差分析和博弈Howell事后检验（α=0.05）。结果两种丙烯酸树脂在不同溶液中浸泡后的生物相容性相似（P=0.400）。浸泡在蒸馏水、3.8%过硼酸钠和0.5%次氯酸钠中不会影响角质形成细胞的细胞代谢（P>0.05），无论浸泡时间和丙烯酸树脂的类型如何（P>0.05）。浸泡在2%二葡萄糖酸洗必泰或苹果醋中，随着时间的推移，直到第三个月，都会产生较高的细胞毒性（P.05）。结论丙烯酸树脂的种类（基树脂或衬树脂）对细胞活力无明显影响。醋和洗必泰二葡萄糖酸盐溶液的细胞毒性随着时间的推移而增强，浸泡6个月后具有强烈的细胞毒性。过硼酸钠和次氯酸钠在所有测试时间段内均无细胞毒性。

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