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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
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Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors

机译：在N-乙酰半胱氨酸和甘氨酸补充饮食后改善旧小鼠的心血管功能：炎症和线粒体因子

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摘要

Metabolic, inflammatory, and functional changes occur in cardiovascular aging which may stem from oxidative stress and be remediable with antioxidants. Glutathione, an intracellular antioxidant, declines with aging, and supplementation with glutathione precursors, N-acetyl cysteine (NAC) and glycine (Gly), increases tissue glutathione. Thirty-month old mice were fed diets supplemented with NAC or NAC+Gly and, after 7 weeks, cardiac function and molecular studies were performed. The NAC+Gly supplementation improved diastolic function, increasing peak early filling velocity, and reducing relaxation time, left atrial volume, and left ventricle end diastolic pressure. By contrast, cardiac function did not improve with NAC alone. Both diet supplementations decreased cardiac levels of inflammatory mediators; only NAC+Gly reduced leukocyte infiltration. Several mitochondrial genes reduced with aging were upregulated in hearts by NAC+Gly diet supplementation. These Krebs cycle and oxidative phosphorylation enzymes, suggesting improved mitochondrial function, and permeabilized cardiac fibers from NAC+Gly-fed mice produced ATP from carbohydrate and fatty acid sources, whereas fibers from control old mice were less able to utilize fatty acids. Our data indicate that NAC+Gly supplementation can improve diastolic function in the old mouse and may have potential to prevent important morbidities for older people.
机译：心血管衰老过程中会发生代谢、炎症和功能变化，这些变化可能源于氧化应激，可通过抗氧化剂修复。细胞内抗氧化剂谷胱甘肽随着衰老而下降，补充谷胱甘肽前体N-乙酰半胱氨酸（NAC）和甘氨酸（Gly）会增加组织谷胱甘肽。给30个月大的小鼠喂食添加NAC或NAC+Gly的饲料，7周后，进行心功能和分子研究。补充NAC+Gly可改善舒张功能，增加峰值早期充盈速度，减少舒张时间、左心房容积和左心室舒张末压。相比之下，单用NAC并不能改善心脏功能。这两种饮食补充都降低了心脏炎症介质的水平；只有NAC+Gly能减少白细胞浸润。通过补充NAC+Gly饮食，随着年龄增长而减少的几个线粒体基因在心脏中上调。这些Krebs循环和氧化磷酸化酶表明线粒体功能得到改善，NAC+Gly喂养的小鼠的通透性心肌纤维从碳水化合物和脂肪酸来源产生ATP，而对照老年小鼠的心肌纤维利用脂肪酸的能力较低。我们的数据表明，补充NAC+Gly可以改善老年小鼠的舒张功能，可能有可能预防老年人的重要疾病。

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