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A Geroscience Perspective on COVID-19 Mortality

机译:关于Covid-19死亡率的大晕透视

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摘要

A novel coronavirus, SARS-CoV-2, emerged in December 2019, leading within a few months to a global pandemic. COVID-19, the disease caused by this highly contagious virus, can have serious health consequences, though risks of complications are highly age-dependent. Rates of hospitalization and death are less than 0.1% in children, but increase to 10% or more in older people. Moreover, at all ages, men are more likely than women to suffer serious consequences from COVID-19. These patterns are familiar to the geroscience community. The effects of age and sex on mortality rates from COVID-19 mirror the effects of aging on almost all major causes of mortality. These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19.
机译:一种新型冠状病毒SARS COV-2在2019年12月出现,在几个月内导致全球大流行。COVID2019冠状病毒疾病,虽然并发症的风险高度依赖年龄,但也会有严重的健康后果。儿童的住院率和死亡率低于0.1%,但老年人的住院率和死亡率增加到10%或以上。此外,在2019冠状病毒疾病中,男性比女性更容易遭受严重后果。这些模式为geroscience社区所熟悉。年龄和性别对2019冠状病毒疾病死亡率的影响反映了衰老对死亡率的几乎所有主要因素的影响。2019冠状病毒疾病的发病机制和治疗结果的相关性,强调了衰老的基本生物学机制对COVID-19潜在治疗和预后的作用。

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