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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project
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Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project

机译：老年人的载脂蛋白e和健康：男性项目中的康科德健康和老龄化

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APOE genotype has been associated with various age-related outcomes including Alzheimer's disease, frailty, and mortality. In this study, the relationship between health, particularly cognitive function, and APOE was investigated in older men from the Concord Health and Ageing in Men Project (n = 1,616; age 76.9 +/- 5.5 years [range 70-97 years]; Australia). Baseline characteristics and survival up to 12 years were determined. Frailty was measured using Cardiovascular Health study (CHS) criteria and Rockwood frailty index, and cognition using Mini-Mental State Examination (MMSE) and Addenbrookes Cognitive Examination. APOE epsilon 4 was less common in the oldest men and those born in Mediterranean countries. APOE epsilon 2 was beneficially associated with cholesterol, creatinine, gamma-glutamyl transaminase, glucose, and HDL cholesterol while APOE epsilon 4 was adversely associated with cholesterol and albumin. APOE epsilon 4 was associated with a clinical diagnosis of Alzheimer's disease when adjusted for age and region of birth (epsilon 4 homozygotes Odds ratio (OR) 7.0; epsilon 4 heterozygotes OR 2.4, p < .05), and APOE epsilon 2 had a small positive association with cognition. On multivariate regression, overall cognitive function in the entire cohort was associated with age, country of birth, education, and frailty (all p < .001). APOE was not associated with frailty or survival. In conclusion, age and region of birth influenced distribution of APOE genotype in older men. Although APOE epsilon 4 was associated with Alzheimer's disease, overall cognitive function in the cohort was associated more strongly with frailty than APOE genotype.
机译：APOE基因型与各种年龄相关的结果相关，包括阿尔茨海默病、虚弱和死亡率。在这项研究中，康科德健康与男性老龄化项目（n=1616；年龄76.9+/-5.5岁[范围70-97岁]；澳大利亚）对老年男性的健康，尤其是认知功能与APOE之间的关系进行了调查。确定基线特征和长达12年的生存率。使用心血管健康研究（CHS）标准和Rockwood虚弱指数测量虚弱，使用简易精神状态检查（MMSE）和Addenbrookes认知检查测量认知。APOEε4在老年男性和地中海国家出生的男性中不太常见。载脂蛋白Eε2与胆固醇、肌酐、γ-谷氨酰转氨酶、葡萄糖和高密度脂蛋白胆固醇有利相关，而载脂蛋白Eε4与胆固醇和白蛋白不利相关。经年龄和出生地区调整后，APOEε4与阿尔茨海默病的临床诊断相关（ε4纯合子比值比（OR）7.0；epsilon 4杂合子或2.4，p<0.05）和APOE epsilon 2与认知有小的正相关。在多元回归分析中，整个队列的整体认知功能与年龄、出生国、教育程度和虚弱程度相关（均p<0.001）。APOE与虚弱或存活无关。总之，年龄和出生地区影响了老年男性中APOE基因型的分布。虽然APOEε4与阿尔茨海默病相关，但与APOE基因型相比，该队列中的整体认知功能与虚弱的相关性更强。

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