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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging Endocrine and Metabolic Phenotypes Are Programmed by Mother's Age at Conception in a Sex-Dependent Fashion in the Rat
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Aging Endocrine and Metabolic Phenotypes Are Programmed by Mother's Age at Conception in a Sex-Dependent Fashion in the Rat

机译：老化内分泌和代谢表型被母亲年龄在概念中以依赖于老鼠的性爱方式编程

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摘要

Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150- than 70- and 90-day mothers. Insulin, glucose, and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex-dependent manner and merits consideration in designing and interpreting programming studies.
机译：通过母亲的营养和压力来规划后代的生命过程健康已经得到了很好的研究。在出生后850天，我们评估了在70、90、150或300天的寿命中繁殖的原始狂犬病姐妹大鼠的老龄后代的雄性和雌性类固醇水平和代谢。在850天的生命中，雄性后代皮质酮与母亲年龄无关。女性皮质酮在70天和300天母亲的后代中最高。血清脱氢表雄酮：在70天和300天母亲的后代中，皮质酮最低。与70天和90天的母亲相比，150天母亲的后代的雄性和雌性脂肪库更小。所有雄性后代的胰岛素、葡萄糖和稳态模型评估结果相似，但70天母亲的雌性后代的胰岛素、葡萄糖和稳态模型评估结果高于其他年龄组。我们得出结论，母亲年龄以一种依赖于后代性别的方式影响后代的衰老，在设计和解释编程研究时值得考虑。

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