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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Shorter Telomere Length in Carriers of APOE-epsilon 4 and High Plasma Concentration of Glucose, Glyoxal and Other Advanced Glycation End Products (AGEs)
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Shorter Telomere Length in Carriers of APOE-epsilon 4 and High Plasma Concentration of Glucose, Glyoxal and Other Advanced Glycation End Products (AGEs)

机译：Apoe-epsilon 4的载体中的较短端粒长度和高血浆浓度的葡萄糖，乙醛和其他先进的糖糖末端产品（年龄）

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摘要

Apolipoprotein-epsilon 4 (APOE-epsilon 4)-common variant is a major genetic risk factor for cognitive decline and Alzheimer's disease (AD). An accelerated rate of biological aging could contribute to this increased risk. Glycation of serum proteins due to excessive glucose and reactive oxygen species leads to the formation of advanced glycation end products (AGEs)-a risk factor for diabetes and AD, and decline in motor functioning in elderly adults. Aim of present study was to investigate impact of APOE-epsilon 4 allele containing genotype and accumulation of AGEs in plasma on telomere length (TL). Results showed that TL is significantly shorter in APOE-epsilon 4 carriers compared with non-APOE-epsilon 4 carriers (p = .0003). Higher plasma glucose level was associated with shorter TL irrespective of APOE-epsilon 4 allele containing genotype (r = -.26; p = .0004). With regard to AGEs, higher plasma glyoxal and fluorescent AGEs concentrations were inversely related to TL (r = -.16; p = .03; r = -.28; p = .0001), however, plasma Ne-(carboxymethyl)lysine levels didn't correlate with TL (r = -.04; p = .57). Results support the hypotheses that APOE-epsilon 4 carriers have shorter telomeres than noncarriers and telomere erosion is increased with higher concentration of glucose, fluorescent AGEs, and glyoxal.
机译：载脂蛋白epsilon 4（APOE epsilon 4）——常见变体是认知功能下降和阿尔茨海默病（AD）的主要遗传风险因素。生物老化的加速可能会增加这种风险。过量的葡萄糖和活性氧导致的血清蛋白糖基化导致晚期糖基化终产物（AGEs）的形成，AGEs是糖尿病和AD的危险因素，并导致老年人运动功能下降。本研究的目的是研究载脂蛋白Eε4等位基因的基因型和血浆中AGEs的累积对端粒长度（TL）的影响。结果显示，与非APOEε4携带者相比，APOEε4携带者的TL显著缩短（p=0.0003）。无论含APOEε4等位基因的基因型如何，较高的血糖水平与较短的TL相关（r=-.26；p=.0004）。关于AGEs，较高的血浆乙二醛和荧光AGEs浓度与TL呈负相关（r=-.16；p=.03；r=-.28；p=.0001），然而，血浆中的氨基酸-（羧甲基）赖氨酸水平与TL无关（r=-.04；p=.57）。结果支持载脂蛋白Eε4携带者的端粒比非携带者短的假设，并且随着葡萄糖、荧光AGE和乙二醛浓度的升高，端粒侵蚀增加。

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