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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Imbalance Between Omega-6-and Omega-3-Derived Bioactive Lipids in Arthritis in Older Adults
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Imbalance Between Omega-6-and Omega-3-Derived Bioactive Lipids in Arthritis in Older Adults

机译：老年人关节炎中ω-6和Omega-3-衍生的生物活性脂质的不平衡

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Elderly-onset rheumatoid arthritis (EORA) and polymyalgia rheumatica (PMR) are common rheumatic diseases in older adults. Oxylipins are bioactive lipids derived from omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) that serve as activators or suppressors of systemic inflammation. We hypothesized that arthritis symptoms in older adults were related to oxylipin-related perturbations. Arthritis in older adults (ARTIEL) is an observational prospective cohort with 64 patients older than 60 years of age with newly diagnosed arthritis. Patients' blood samples at baseline and 3 months posttreatment were compared with 18 controls. A thorough clinical examination was conducted. Serum oxylipins were determined by mass spectrometry. Data processing and statistical analysis were performed in R. Forty-four patients were diagnosed with EORA and 20 with PMR. At diagnosis, EORA patients had a mean DAS28CRP (Disease Activity Score 28 using C-reactive protein) of 5.77 (SD 1.02). One hundred percent of PMR patients reported shoulder pain and 90% reported pelvic pain. Several n-6- and n-3-derived oxylipin species were significantly different between controls and arthritis patients. The ratio of n-3/n-6 PUFA was significantly downregulated in EORA but not in PMR patients as compared to controls. The top two candidates as biomarkers for differentiating PMR from EORA were 4-HDoHE, a hydroxydocosahexaenoic acid, and 8,15-dihydroxy-eicosatrienoic acid (8,15-diHETE). The levels of n-3-derived anti-inflammatory species increased in EORA after treatment. These results suggest that certain oxylipins may be key effectors in arthrtis in older adults and that the imbalance between n-6- and n-3-derived oxylipins might be related to pathobiology in this population.
机译：老年性风湿性关节炎（EORA）和风湿性多肌痛（PMR）是老年人常见的风湿性疾病。氧化脂质是从ω-6（n-6）和ω-3（n-3）多不饱和脂肪酸（PUFA）中提取的生物活性脂质，用作全身炎症的激活剂或抑制剂。我们假设老年人的关节炎症状与氧化脂质相关的紊乱有关。老年人关节炎（ARTIEL）是一个前瞻性观察队列，有64名60岁以上的新诊断关节炎患者。将患者在基线检查时和治疗后3个月的血样与18名对照组进行比较。进行了彻底的临床检查。用质谱法测定血清氧化脂质。对R进行数据处理和统计分析。44名患者被诊断为EORA，20名患者被诊断为PMR。诊断时，EORA患者的平均DAS28CRP（使用C反应蛋白的疾病活动评分28）为5.77（SD 1.02）。100%的PMR患者报告肩部疼痛，90%报告骨盆疼痛。在对照组和关节炎患者之间，几种n-6和n-3衍生的氧化脂质物种存在显著差异。与对照组相比，EORA患者的n-3/n-6多不饱和脂肪酸比例显著下调，但PMR患者的n-3/n-6多不饱和脂肪酸比例没有下调。区分PMR和EORA的前两个候选生物标志物是4-HDoHE（一种羟基二十二碳六烯酸）和8,15-二羟基二十碳三烯酸（8,15-二羟基二十碳三烯酸）。治疗后，EORA中n-3衍生抗炎物质的水平增加。这些结果表明，某些氧化脂质可能是老年人关节炎的关键效应因子，n-6-和n-3-衍生氧化脂质之间的不平衡可能与该人群的病理生物学有关。

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