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首页> 外文期刊>The lancet oncology >Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 2 Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
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Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 2 Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

机译：儿童，青少年和年轻成人癌症的生育保存2儿童，青少年和年轻成人癌症的男性患者的生育保存：潘加里术联盟的建议与儿童癌症指南协调小组的国际晚期影响

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Male patients with childhood, adolescent, and young adult cancer are at an increased risk for infertility if their treatment adversely affects reproductive organ function. Future fertility is a primary concern of patients and their families. Variations in clinical practice are barriers to the timely implementation of interventions that preserve fertility. As part of the PanCareLIFE Consortium, in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in male patients who are diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the available evidence and to form the recommendations. Recognising the need for global consensus, this clinical practice guideline used existing evidence and international expertise to rigorously develop transparent recommendations that are easy to use to facilitate the care of male patients with childhood, adolescent, and young adult cancer who are at high risk of fertility impairment and to enhance their quality of life.
机译：患有儿童、青少年和青年癌症的男性患者，如果其治疗对生殖器官功能产生不利影响，则其不孕的风险会增加。未来的生育能力是患者及其家人最关心的问题。临床实践中的差异阻碍了及时实施保护生育能力的干预措施。作为PanCareLIFE联盟的一部分，我们与国际儿童癌症晚期效应指南协调小组合作，审查了当前的文献，并为25岁或以下被诊断为儿童、青少年和青年癌症的男性患者制定了保留生育能力的临床实践指南，包括风险评估指南和生育能力保存的可用方法。建议评级评估、开发和评估方法用于对现有证据进行评级并形成建议。认识到全球共识的必要性，本临床实践指南利用现有证据和国际专业知识，严格制定透明的建议，易于使用，以促进对患有儿童、青少年和青年癌症的男性患者的护理，这些男性患者具有生育障碍的高风险，并提高他们的生活质量。

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