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首页> 外文期刊>The American Journal of Cardiology >Relation of Late Gadolinium Enhancement and Extracellular Volume Fraction to Ventricular Arrhythmias in Hypertrophic Cardiomyopathy
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Relation of Late Gadolinium Enhancement and Extracellular Volume Fraction to Ventricular Arrhythmias in Hypertrophic Cardiomyopathy

机译：晚期钆增强和细胞外体积分数对肥厚性心肌病的室性心律失常的关系

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Hypertrophic cardiomyopathy (HC) represents a major cause of sudden cardiac death in young adults. Late gadolinium enhancement (LGE) and extracellular volume (ECV) by T1 mapping are cardiac magnetic resonance (CMR) techniques to quantify fibrosis in HC. The relationships of LGE and ECV with ventricular arrhythmia, left ventricular (LV) diastolic function, and risk factors for sudden cardiac death (SCD) in HC are unclear. We studied 103 HC patients (mean age 51 +/- 14, 42% women) who underwent CMR from 2012 to 2014. Global LGE and mean ECV were evaluated in relation to history of nonsustained ventricular tachycardia (NSVT), diastolic function by echocardiography, and SCD risk factors. LGE was present in 71 (69%) subjects. Wide variation was demonstrated in LGE (0.5% to 45.9%) and mean ECV (17.6% to 47.4%). Prevalence of NSVT increased continuously with LGE and was greater in subjects with ECV above the study population mean (27%). Increased LGE was associated with LV diastolic dysfunction and LV wall thickness. In conclusion, while ECV appears to have a threshold (27%) above which it is associated with NSVT, LGE demonstrates a more robust relationship with NSVT and measures of diastolic dysfunction. (C) 2020 Elsevier Inc. All rights reserved.
机译：肥厚型心肌病（HC）是年轻人心脏性猝死的主要原因。T1标测的晚期钆增强（LGE）和细胞外体积（ECV）是量化HC纤维化的心脏磁共振（CMR）技术。LGE和ECV与HC患者室性心律失常、左室舒张功能和心源性猝死（SCD）危险因素的关系尚不清楚。我们研究了103名2012年至2014年接受CMR的HC患者（平均年龄51+/-14岁，42%为女性）。评估整体LGE和平均ECV与非持续性室性心动过速（NSVT）病史、超声心动图舒张功能和SCD风险因素的关系。71名受试者（69%）出现LGE。LGE（0.5%至45.9%）和平均ECV（17.6%至47.4%）存在较大差异。NSVT的患病率随着LGE不断增加，ECV患者的患病率高于研究人群的平均值（27%）。LGE增加与左室舒张功能障碍和左室壁厚度有关。总之，虽然ECV似乎有一个阈值（27%），高于该阈值时，它与NSVT相关，但LGE与NSVT和舒张功能不全指标的关系更为密切。（C） 2020爱思唯尔公司版权所有。

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