Nonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement

Gryaznov Anton A.; Saeyeldin Ayman; Abdelbaky Mohamad; Zafar Mohammad A.; Tanweer Maryam; Papanikolaou Dimitra; Imran Mahnoor; Li Yupeng; Ziganshin Bulat A.; Elefteriades John A.

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Nonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement

机译：手术生物疗法主动脉瓣膜置换后的抗血栓治疗的抗血栓治疗的不合适

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Controversy persists regarding the advisability of anticoagulation for the early period after biological surgical aortic valve replacement (AVR). We aim to examine the impact of various antithrombotic regimens on outcomes in a large cohort of biological AVR patients. Records of 1,111 consecutive adult patients who underwent surgical biological AVR at our institution between 2013 and 2017 were reviewed. Outcomes included stroke, bleeding, and death at 3 and 12 months. Treatment regimens included (1) no therapy, (2) anticoagulants (warfarin or Factor Xa inhibitors), (2) antiplateles (various), and (4) anticoagulants + antiplatelets. Kaplan-Meier analysis was used to track outcomes, and Cox-proportional hazards regression models were conducted to analyze effects of different therapies on adverse events.

机译：关于生物外科主动脉瓣置换术（AVR）后早期抗凝是否可取的争议依然存在。我们的目的是在一大组生物性AVR患者中研究各种抗血栓治疗方案对预后的影响。回顾了2013年至2017年间在我们机构接受外科生物AVR的1111名连续成年患者的记录。结果包括3个月和12个月时的中风、出血和死亡。治疗方案包括（1）不治疗，（2）抗凝剂（华法林或Xa因子抑制剂），（2）抗血小板（各种），以及（4）抗凝剂+抗血小板。Kaplan-Meier分析用于追踪结果，Cox比例风险回归模型用于分析不同疗法对不良事件的影响。

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来源
《The American Journal of Cardiology》 |2020年第1期|共8页
作者
Gryaznov Anton A.; Saeyeldin Ayman; Abdelbaky Mohamad; Zafar Mohammad A.; Tanweer Maryam; Papanikolaou Dimitra; Imran Mahnoor; Li Yupeng; Ziganshin Bulat A.; Elefteriades John A.;
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Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

Yale Univ Aort Inst Yale New Haven Hosp Sch Med New Haven CT 06520 USA;

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正文语种 eng
中图分类心脏、血管（循环系）疾病;
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1. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: a meta analysis [J] . WU Yi-cheng, ZHANG Jian-feng, SHEN Wei-feng, 中华医学杂志（英文版） . 2013,第006期
2. A meta-analysis of 1-year outcomes of transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis [J] . Aaqib H Malik, Syed Zaid, Hasan Ahmad, 老年心脏病学杂志（英文版） . 2020,第001期
3. Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis [J] . Tsigkas Grigorios, Despotopoulos Stefanos, Makris Athanasios, 老年心脏病学杂志（英文版） . 2018,第001期
4. Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass [J] . Gryaznov Anton A., Saeyeldin Ayman, Abdelbaky Mohamed, Cardiology . 2018,第4期

机译：生物假体主动脉瓣膜置换后的抗血栓形成治疗：治疗莫拉斯
5. Early Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement in Elderly Patients: A Single-Center Experience [J] . Lee Seok In, Lee Kyo Seon, Kim Joon Bum, Annals of thoracic and cardiovascular surgery: official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia . 2017,第3期

机译：早期的抗血栓检查在老年患者中的生物假体主动脉瓣膜置换术后：单中心经验
6. Antithrombotic therapy after bioprosthetic aortic valve replacement: ACTION Registry survey results. [J] . Colli A, Verhoye JP, Heijmen R, European journal of cardio-thoracic surgery: Official journal of the European Association for Cardio-thoracic Surgery . 2008,第4期

机译：生物人工主动脉瓣置换后的抗血栓治疗：ACTION Registry调查结果。
7. Complexity and Nonlinearities of Short-Term Cardiovascular and Cerebrovascular Controls after Surgical Aortic Valve Replacement [C] . Alberto Porta, Angela Fantinato, Vlasta Bari, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2020

机译：外科主动脉瓣置换术后短期心脑血管控制的复杂性和非线性
8. Evaluating bioprosthetic devices in aortic valve surgery: Systematic assessment and design of cardiac surgical trials. [D] . Semelhago, Lloyd C. 2005

机译：在主动脉瓣手术中评估生物修复装置：心脏外科手术试验的系统评估和设计。
9. Early Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement in Elderly Patients: A Single-Center Experience [O] . Seok In Lee, Kyo Seon Lee, Joon Bum Kim, 2017

机译：老年患者人工生物瓣膜置换术后的早期抗栓治疗：单中心经验
10. WHAT ARE THE CURRENT PRACTICES IN ANTITHROMBOTIC THERAPY AFTER BIOPROSTHETIC AORTIC VALVE REPLACEMENT: A MULTICENTER PATIENT–BASED STUDY [O] . Bouleti Claire, Leguerrier Alain, Obadia Jean–Francois, 2013

机译：双瓣式主动脉瓣置换术后抗蝶药物治疗的最新实践：基于多中心患者的研究
11. Congenital Aortic Stenosis Secondary to Dysplasia of Congenital Bicuspid Aortic Valves without Commissural Fusion. [R] . Cheitlin, M. D., Fenoglio, J. J., McAllister, H. A., 1977

机译：先天性主动脉瓣狭窄继发于先天性双尖瓣主动脉瓣发育不良而没有连合融合。

Nonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement

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