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首页> 外文期刊>The American Journal of Cardiology >Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout
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Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout

机译：心力衰竭患者的特征和结果比较射入射血馏分与无高尿酸血症或痛风

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摘要

Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke University Health System to describe characteristics of patients with HFpEF and hyperuricemia (serum uric acid >6 mg/dl) or gout (gout diagnosis or gout medication within the previous year) and to explore associations with 5-year outcomes (death and hospitalization). We identified 7,004 patients in the Duke University Health System with a known diagnosis of HFpEF who underwent transthoracic echocardiography between January 1, 2005 and December 31, 2017. A total of 1,136 (16.2%) patients with HFpEF also had hyperuricemia or gout. Patients with HFpEF and hyperuricemia or gout had a greater comorbidity burden, more echocardiographic findings of cardiac remodeling, and higher unadjusted rates of all-cause death, all-cause hospitalization, and HF hospitalization compared with those with HFpEF without hyperuricemia or gout. After multivariable adjustment, patients with HFpEF and hyperuricemia or gout had a significantly higher rates of first all-cause hospitalization (adjusted hazard ratio 1.10 [95% confidence interval 1.02 to 1.19]; p = 0.020) and recurrent all-cause hospitalization (associated rate ratio 1.13 [95% confidence interval 1.01 to 1.25]; p = 0.026). After adjustment, no significant differences in death or HF hospitalization were observed. In conclusion, patients with HFpEF and hyperuricemia or gout were found to have a higher burden of comorbidities and a higher rate of all-cause hospitalization, even after multivariable adjustment, compared to patients with HFpEF without hyperuricemia or gout. (C) 2020 Elsevier Inc. All rights reserved.
机译：高尿酸血症和痛风在心力衰竭（HF）患者中很常见，与不良预后相关。描述射血分数保留的HF患者高尿酸血症和痛风的数据有限。我们使用杜克大学卫生系统的数据来描述HFpEF和高尿酸血症（血清尿酸>6 mg/dl）或痛风（痛风诊断或前一年内的痛风药物治疗）患者的特征，并探讨其与5年预后（死亡和住院）的关系。我们在杜克大学卫生系统中确定了7004名已知诊断为HFpEF的患者，他们在2005年1月1日至2017年12月31日期间接受了经胸超声心动图检查。共有1136名HFpEF患者（16.2%）患有高尿酸血症或痛风。与无高尿酸血症或痛风的HFpEF患者相比，HFpEF患者和高尿酸血症或痛风患者的共病负担更大，心脏重构的超声心动图结果更多，全因死亡、全因住院和HF住院的未调整率更高。经过多变量调整后，HFpEF和高尿酸血症或痛风患者的首次全因住院率（调整后的危险比1.10[95%可信区间1.02至1.19]；p=0.020）和复发性全因住院率（相关比率1.13[95%可信区间1.01至1.25]；p=0.026）显著较高。调整后，死亡或心衰住院率无显著差异。总之，与无高尿酸血症或痛风的HFpEF患者相比，即使经过多变量调整，HFpEF患者合并高尿酸血症或痛风的负担更高，全因住院率也更高。（C） 2020爱思唯尔公司版权所有。

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