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首页> 外文期刊>The American Journal of Cardiology >Usefulness of Interleukin-1 Receptor Antagonists in Patients With Recurrent Pericarditis
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Usefulness of Interleukin-1 Receptor Antagonists in Patients With Recurrent Pericarditis

机译:白细胞介素-1受体拮抗剂在复发性心包炎患者中的用量

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摘要

Nonsteroidal anti-inflammatory drugs and colchicine remain the standard of care as the initial treatment of acute pericarditis. Corticosteroids and traditional immunosuppressive medications are often added if patients develop recurrent symptoms and remain medically refractory. There has been growing interest in the use of interleukin-1 receptor antagonists (IL-1RAs) in managing pericarditis, especially, in medically refractory cases. Anakinra-Treatment for Recurrent Idiopathic Pericarditis is a recent pilot trial showing a benefit of using the IL-1RA, anakinra, in recurrent pericarditis. Publications remain limited and more outcomes trials are needed. This review focuses on the mechanism of action, clinical utility, current, and future studies that investigate the role of IL-1RAs in the management of recurrent pericarditis. (C) 2020 Elsevier Inc. All rights reserved.
机译:非甾体抗炎药和秋水仙碱仍然是急性心包炎初期治疗的标准。如果患者出现复发性症状并在医学上仍难治,通常会添加皮质类固醇和传统的免疫抑制药物。使用白细胞介素-1受体拮抗剂(IL-1RAs)治疗心包炎的兴趣越来越大,尤其是在药物难治性病例中。Anakina治疗复发性特发性心包炎是最近的一项试点试验,表明在复发性心包炎中使用IL-1RA(Anakina)是有益的。出版物仍然有限,需要更多的临床试验结果。本文综述IL-1RAs在复发性心包炎治疗中的作用机制、临床应用、当前和未来研究。(C) 2020爱思唯尔公司版权所有。

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