A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation

Ball Alexandra L.; Edge Rebecca J.; Amin Kavit; Critchley William R.; Howell Gareth J.; Yonan Nizar; Stone John P.; Fildes James E.

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A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation

机译：保存后的血管冲洗在肺移植之前去除过度的供体白细胞群体

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Background: Donor leukocytes are intrinsically involved in acute lung allograft rejection, via self-presentation of donor antigens to recipient leukocytes. Therapeutic modalities to remove donor leukocytes are currently unavailable. We evaluated if a vascular flush immediately following preservation can be used for this purpose.

机译：背景：供体白细胞通过自身将供体抗原呈递给受体白细胞，本质上参与了肺移植急性排斥反应。目前还没有清除供体白细胞的治疗方法。我们评估了保存后立即进行的血管冲洗是否可用于此目的。

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来源
《Transplant immunology》 |2021年第1期|共7页
作者
Ball Alexandra L.; Edge Rebecca J.; Amin Kavit; Critchley William R.; Howell Gareth J.; Yonan Nizar; Stone John P.; Fildes James E.;
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作者单位

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester Manchester Acad Hlth Sci Ctr Fac Biol Med &

Hlth Flow Cytometry Core Facil;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

Univ Manchester NHS Fdn Trust Transplant Ctr Manchester M23 9LT Lancs England;

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原文格式 PDF
正文语种 eng
中图分类器官移植术;
关键词
Lung transplantation; Acute rejection; Passenger leukocytes; Preservation; Ischaemia-reperfusion injury;

机译：肺移植;急性排斥;乘客白细胞;保存;缺血再灌注损伤;

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1. Bilateral lobar lung transplantation and a single lung transplantation using lungs from a single organ donor during coronavirus disease 2019 pandemic [J] . Feng Liu, Michael K.Y.Hsin, Ming Wu, 中华医学杂志（英文版） . 2021,第017期
2. Role of human leukocyte antigen molecules in selecting potential donors for allogeneic hematopoietic stem cell transplantation [J] . He Jun 中华医学杂志（英文版） . 2014,第007期
3. Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors [J] . Cao Tingting, Li Yanfen, Wang Quanshun, 中华医学杂志（英文版） . 2014,第014期
4. Improved lung function by means of retrograde flush in canine lung transplantation with non-heart-beating donors [J] . Makio Hayama, Hiroshi Date, Takahiro Oto, The journal of thoracic and cardiovascular surgery . 2003,第4期

机译：在非心跳供体的犬肺移植中通过逆行冲洗改善肺功能
5. Improved lung function by means of retrograde flush in canine lung transplantation with non-heart-beating donors. [J] . Hayama M, Date H, Oto T, The Journal of Thoracic and Cardiovascular Surgery . 2003,第4期

机译：在无心跳供体的犬肺移植中通过逆行冲洗改善肺功能。
6. Late-onset Rejection of a Unilateral Donor Lung with Vascular C4d Deposition in Bilateral Living-donor Lobar Lung Transplantation: An Autopsy Case Report [J] . Yamamoto Hiroshi, Yoshida Kazuo, Koizumi Tomonobu, Internal medicine. . 2014,第15期

机译：双边活体供体大叶肺移植中伴有血管C4d沉积的单侧供体肺的迟发性排斥反应：尸检病例报告
7. DONOR SPECIFIC ANTIBODIES WITH OR WITHOUT POSITIVE C4D STAINING ARE CORRELATED WITH AMR AND/OR BOS IN LUNG TRANSPLANT RECIPIENTS [C] . Marilyn S. Pollack, Deborah J. Levine, Sherry L. Werner, Clinical Histocompatibility Workshop. . 2009

机译：具有或不具有阳性C4D染色的供体特异性抗体与肺移植受者的AMR和/或BOS相关联
8. Increasing the donor pool for lung transplantation: Low tidal volume mechanical ventilation strategies in the brain dead potential lung donor patient. [D] . Jacobson, Alice Kelley. 2016

机译：增加用于肺移植的供体库：潜在的脑死亡肺供体患者的低潮气量机械通气策略。
9. Ex Vivo Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation [O] . John P. Stone, Alexandra L. Ball, William R. Critchley, 2016

机译：前体内正常体温灌注诱导肾移植前供体来源的白细胞动员和去除
10. Improved lung function by means of retrograde flush in canine lung transplantation with non-heart-beating donors [O] . Hayama Makio, Date Hiroshi, Oto Takahiro, 2003

机译：在非心跳供体的犬肺移植中通过逆行冲洗改善肺功能
11. Testing Leukocyte Antisera on Lymphocytes of Kidney Transplant Patients and Donors, Redirected to: Production of Grouped Leukocyte Typing Sera [R] . Terasaki, P. I. 1966

机译：测试肾移植患者和供体淋巴细胞上的白细胞抗血清，重定向：分组白细胞分型血清的产生

A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation

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