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首页> 外文期刊>Trends in Plant Science >Physiological Genetics Reformed: Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints - the Global Coordinator
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Physiological Genetics Reformed: Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints - the Global Coordinator

机译:改造的生理遗传学:通过相干化学指纹桥接基因组到苯缺陷 - 全球协调员

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摘要

Forward-focused molecular genetics is successfully framing DNA diversity and mapping primary gene functions. However, abandoning the classic Linnaean fingerprint link between the phenome and genome by suppressing gene interaction (pleiotropy), has resulted in a genome-to-phenome gap and poor utilization of molecular data. We demonstrate how to bridge this gap by using an example of a barley mutant seed model, where pleiotropy is observed as covarying global molecular patterns that define each endosperm. Global coherence was discovered as a covariate coordinator within and between local genotype specific fingerprints. This implies that any of these fingerprints can select its recombinant global phenotype variant, including composition. Introducing the law of coherence, and the movement of gene complexes by chemical fingerprint traits as selectors, introduces a revolution in understanding physiological molecular genetics and plant-breeding.
机译:前沿分子遗传学成功地构建了DNA多样性,并绘制了主要基因功能图。然而,通过抑制基因相互作用(多效性),放弃了表型和基因组之间的经典林奈指纹联系,导致了基因组-表型差距和分子数据利用率低下。我们以大麦突变种子模型为例,展示了如何弥合这一差距,在该模型中,多效性被观察为定义每个胚乳的共价全局分子模式。全球一致性被发现是局部基因型特异性指纹内部和之间的协变量协调器。这意味着这些指纹中的任何一个都可以选择其重组的全局表型变体,包括成分。引入一致性定律,以及通过化学指纹特征作为选择子来移动基因复合体,将在理解生理分子遗传学和植物育种方面带来一场革命。

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  • 来源
    《Trends in Plant Science》 |2021年第4期|共14页
  • 作者单位

    Univ Copenhagen Chemometr &

    Analyt Technol Dept Food Sci Rolighedsvej 26 DK-1958 Copenhagen Denmark;

    Univ Copenhagen Chemometr &

    Analyt Technol Dept Food Sci Rolighedsvej 26 DK-1958 Copenhagen Denmark;

    Univ Copenhagen Chemometr &

    Analyt Technol Dept Food Sci Rolighedsvej 26 DK-1958 Copenhagen Denmark;

    Univ Copenhagen Chemometr &

    Analyt Technol Dept Food Sci Rolighedsvej 26 DK-1958 Copenhagen Denmark;

    Univ Copenhagen Chemometr &

    Analyt Technol Dept Food Sci Rolighedsvej 26 DK-1958 Copenhagen Denmark;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 植物学;
  • 关键词

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