Diversity and Function of Glial Cell Types in Multiple Sclerosis

Schirmer Lucas; Schafer Dorothy P.; Bartels Theresa; Rowitch David H.; Calabresi Peter A.

首页> 外文期刊>Trends in immunology >Diversity and Function of Glial Cell Types in Multiple Sclerosis

【24h】

Diversity and Function of Glial Cell Types in Multiple Sclerosis

机译：多发性硬化症中胶质细胞类型的多样性与功能

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory-demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled 'mapping back' dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS.

机译：神经胶质亚型多样性是神经生物学和免疫介导的神经疾病如多发性硬化症（MS）中的一个新兴话题。我们讨论了最近的概念和技术进展，这些进展有助于更好地理解炎症脱髓鞘条件下少突胶质细胞（OLs）、星形胶质细胞和小胶质细胞的转录组学和功能异质性。最近的单细胞转录组学研究表明，出现了新的稳态和反应性神经胶质亚型，并为疾病进展过程中的分子事件提供了见解。多重RNA原位杂交能够将失调的基因表达“映射回”MS病变微环境中的神经胶质亚型。这些发现表明，在免疫相关过程和与理解MS病理相关的神经保护中，新的稳态和反应性胶质细胞类型的功能。

著录项

来源
《Trends in immunology》 |2021年第3期|共20页
作者
Schirmer Lucas; Schafer Dorothy P.; Bartels Theresa; Rowitch David H.; Calabresi Peter A.;
展开▼
作者单位

Heidelberg Univ Med Fac Mannheim Dept Neurol Mannheim Germany;

Univ Massachusetts Dept Neurobiol Med Sch Worcester MA 01605 USA;

Univ Cambridge Wellcome MRC Cambridge Stem Cell Inst Dept Paediat Cambridge England;

Univ Cambridge Wellcome MRC Cambridge Stem Cell Inst Dept Paediat Cambridge England;

Johns Hopkins Sch Med Dept Neurol Baltimore MD 21205 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation [J] . Coram Guevara, Fernando C. Ortiz 中国神经再生研究（英文版） . 2021,第003期
2. Programmed cell death and natural killer cells in multiple sclerosis：new potential therapeutic targets? [J] . Beatrice Macchi, Antonio Mastino 中国神经再生研究（英文版） . 2016,第005期
3. Secretion of nerve growth factor, brain-derived neurotrophic factor, and glial cell-line derived neurotrophic factor in co-culture of four cell types in cerebrospinal fluid-containing medium [J] . Sanjiang Feng, Minghua Zhuang, Rui Wu 中国神经再生研究（英文版） . 2012,第036期
4. The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis [J] . Samuel S.Duffy, Justin G.Lees, GilaMoalem-Taylor Multiple Sclerosis International . 2014,第1期

机译：免疫和胶质细胞类型在实验性自身免疫性脑脊髓炎和多发性硬化中的贡献
5. Diversity of Immune Cell Types in Multiple Sclerosis and Its Animal Model: Pathological and Therapeutic Implications [J] . Cheng Yun, Sun Li, Xie Zhongxiang, Journal of Neuroscience Research . 2017,第10期

机译：多发性硬化和动物模型中免疫细胞类型的多样性：病理与治疗意义
6. Innate immunity modulates autoimmunity: type 1 interferon-beta treatment in multiple sclerosis promotes growth and function of regulatory invariant natural killer T cells through dendritic cell maturation. [J] . Gigli G, Caielli S, Cutuli D, Immunology: An Official Journal of the British Society for Immunology . 2007,第3期

机译：先天性免疫调节自身免疫：多发性硬化症中的1型干扰素-β治疗通过树突状细胞成熟促进了调节性天然杀伤性T细胞的生长和功能。
7. An antigen-specific microparticle system ameliorates autoimmunity in mouse models of type 1 diabetes and multiple sclerosis [C] . Joshua M. Stewart, Jamal S. Lewis, Alex J. Kwiatowski, Society for Biomaterials annual meeting and exposition . 2019

机译：抗原特异性微粒系统可改善1型糖尿病和多发性硬化症小鼠模型的自身免疫
8. Effect of liver X receptor agonist on glial activation: Relevance to multiple sclerosis [D] . Gandhi, Cindy Zhang 2007

机译：肝X受体激动剂对神经胶质激活的影响：与多发性硬化症的相关性。
9. The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis [O] . Samuel S. Duffy, Justin G. Lees, Gila Moalem-Taylor 2014

机译：免疫和胶质细胞类型在实验性自身免疫性脑脊髓炎和多发性硬化中的贡献
10. Diversity and Function of Glial Cell Types in Multiple Sclerosis [O] . Lucas Schirmer, Dorothy P. Schafer, Theresa Bartels, 2021

机译：多发性硬化症中胶质细胞类型的多样性与功能
11. Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis. [R] . Mowry, E., Newsome, S., Avornu, A. 2017

机译：鼻内胰岛素改善多发性硬化症的认知功能。

Diversity and Function of Glial Cell Types in Multiple Sclerosis

摘要

著录项

相似文献

相关主题

期刊订阅