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首页> 外文期刊>Trends in Microbiology >Breach: Host Membrane Penetration and Entry by Nonenveloped Viruses
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Breach: Host Membrane Penetration and Entry by Nonenveloped Viruses

机译：违规：非营成病毒的主体膜渗透和进入

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摘要

Disruption of host membranes by nonenveloped viruses, which allows the nucleocapsid or genome to enter the cytosol, is a mechanistically diverse process. Although the membrane-penetrating agents are usually small, hydrophobic or amphipathic peptides deployed from the capsid interior during entry, their manner of membrane interaction varies substantially. In this review, we discuss recent data about the molecular pathways for externalization of viral peptides amidst conformational alterations in the capsid, as well as mechanisms of membrane penetration, which is influenced by structural features of the peptides themselves as well as physicochemical properties of membranes, and other host factors. The membrane-penetrating components of nonenveloped viruses constitute an interesting class of cell-penetrating peptides, and may have potential therapeutic value for gene transfer.
机译：非包膜病毒破坏宿主膜，使核衣壳或基因组进入胞浆，是一个机制多样的过程。尽管膜渗透剂通常是在进入过程中从衣壳内部部署的小的、疏水的或两亲性的肽，但它们的膜相互作用方式有很大不同。在这篇综述中，我们讨论了病毒肽在衣壳构象改变中外化的分子途径的最新数据，以及受肽本身的结构特征、膜的物理化学性质和其他宿主因素影响的膜穿透机制。非包膜病毒的膜穿透成分构成了一类有趣的细胞穿透肽，可能对基因转移具有潜在的治疗价值。

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