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'Omic' Approaches to Study Uropathogenic Escherichia coli Virulence

机译:“OMIC”方法研究尿羟疗法的大肠杆菌毒力

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Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple 'omic' technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.
机译:尿致病性大肠杆菌(UPEC)是一种对全球人类健康具有重要意义的病原体,与快速增加的抗生素耐药性密切相关。UPEC是尿路感染(UTI)的主要原因,该疾病涉及与宿主相互作用期间细胞外和细胞内生活方式的复杂致病途径。多种“组学”技术的应用,包括基因组学、转录组学、蛋白质组学和代谢组学,为我们理解UPEC生物学提供了大量知识。在这里,我们概述了这一进展,并展望了未来的发展,使用这些激动人心的前沿技术来全面理解UPEC在感染背景下的发病机制。

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