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Challenges of Studying the Human Virome - Relevant Emerging Technologies

机译:研究人体病毒与相关新兴技术的挑战

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摘要

In this review we provide an overview of current challenges and advances in bacteriophage research within the growing field of viromics. In particular, we discuss, from a human virome study perspective, the current and emerging technologies available, their limitations in terms of de novo discoveries, and possible solutions to overcome present experimental and computational biases associated with low abundance of viral DNA or RNA. We summarize recent breakthroughs in metagenomics assembling tools and single-cell analysis, which have the potential to increase our understanding of phage biology, diversity, and interactions with both the microbial community and the human body. We expect that these recent and future advances in the field of viromics will have a strong impact on how we develop phage-based therapeutic approaches.
机译:在这篇综述中,我们概述了在病毒组学的不断发展领域中噬菌体研究的当前挑战和进展。特别是,我们从人类病毒组研究的角度讨论了现有和新兴的技术,它们在从头发现方面的局限性,以及克服目前与病毒DNA或RNA丰度低相关的实验和计算偏差的可能解决方案。我们总结了最近在宏基因组学组装工具和单细胞分析方面的突破,它们有可能增加我们对噬菌体生物学、多样性以及与微生物群落和人体的相互作用的理解。我们预计,病毒组学领域最近和未来的进展将对我们如何开发基于噬菌体的治疗方法产生重大影响。

著录项

  • 来源
    《Trends in Microbiology》 |2021年第2期|共11页
  • 作者单位

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

    Environm &

    Climate Change Canada ECCC Aquat Contaminants Res Div ACRD Montreal PQ H2Y 2E7 Canada;

    Helmholtz Ctr Munich Inst Virol D-85764 Neuherberg Bavaria Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

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