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首页> 外文期刊>Western journal of nursing research >Genetic Correlates of Fatigue in Individuals with End Stage Renal Disease
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Genetic Correlates of Fatigue in Individuals with End Stage Renal Disease

机译：胎儿肾疾病中个体疲劳的遗传相关性

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摘要

Fatigue is a prevalent symptom associated with decreased quality of life and increased mortality in individuals with end stage renal disease (ESRD), yet causes of fatigue in individuals with ESRD remain poorly understood. We examined gene expression of Neuronal PAS Domain Protein 2 (NPAS2) in relation to patient-reported fatigue in 122 individuals with ESRD. Independent samples t-tests were used to examine NPAS2 gene expression profiles of: non-fatigue versus fatigue. Multivariable regression analyses were used to examine the relationship between fatigue and numerous variables including depression. Participants were approximately 58 years old (+/- 13.2 years), 78% African American (n = 95), and 72% male (n = 88). The phenotype of fatigue was not significantly associated with gene expression of NPAS2 but was significantly associated with depression (p< .001). This study suggests that further research should examine the causal mechanism between depression and fatigue in order to identify genetic factors that could explain the high comorbidity of depression and fatigue.
机译：在终末期肾病（ESRD）患者中，疲劳是一种普遍的症状，与生活质量下降和死亡率增加有关，但对ESRD患者疲劳的原因仍知之甚少。我们在122名ESRD患者中检测了神经元PAS结构域蛋白2（NPAS2）的基因表达与患者报告的疲劳相关。独立样本t检验用于检测非疲劳与疲劳的NPAS2基因表达谱。多变量回归分析用于检验疲劳与包括抑郁症在内的众多变量之间的关系。参与者约58岁（+/-13.2岁），78%为非裔美国人（n=95），72%为男性（n=88）。疲劳表型与NPAS2基因表达无显著相关性，但与抑郁显著相关（p<0.001）。这项研究表明，应进一步研究抑郁症和疲劳之间的因果机制，以确定可以解释抑郁症和疲劳高度共病的遗传因素。

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