When to consider liver transplantation in hepatocellular carcinoma patients?

Ka Wing Ma; Tan To Cheung

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When to consider liver transplantation in hepatocellular carcinoma patients?

机译：何时考虑肝细胞癌患者的肝移植？

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Orthotopic liver transplantation (LT) has been regarded as the best cure among the three curative treatment modalities. However, when to consider LT in hepatocellular carcinoma (HCC) patients remains a complicated clinical question. In this article, we will look into the recent updates in the context of LT for HCC, including the timing of orthotopic LT (primary or salvage LT), patient selection criteria, newer prognostic markers and scoring systems, down-staging and bridging therapy, salvage LT and treatment option of post-LT HCC recurrence. Evolution of immunosuppressive therapy and future development of the LT for HCC will also be discussed.

机译：在三种治疗方法中，原位肝移植被认为是最好的治疗方法。然而，在肝细胞癌（HCC）患者中考虑LT仍然是一个复杂的临床问题。在这篇文章中，我们将探讨肝癌肝移植的最新进展，包括原位肝移植（原发性肝移植或挽救性肝移植）的时机、患者选择标准、较新的预后标志物和评分系统、下行分期和桥接治疗、挽救性肝移植和肝移植后肝癌复发的治疗选择。还将讨论免疫抑制疗法的演变和肝细胞癌LT的未来发展。

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来源
《Hepatic oncology.》 |2017年第4期|共10页
作者
Ka Wing Ma; Tan To Cheung;
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作者单位

Department of Surgery Queen Mary Hospital the University of Hong Kong Hong Kong;

Department of Surgery Queen Mary Hospital the University of Hong Kong Hong Kong;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. A three-factor preoperative scoring model pre-dicts risk of recurrence after liver resection or transplantation in hepatocellular carcinoma patients with preserved liver function [J] . Nan Jiang 国际肝胆胰疾病杂志（英文版） . 2015,第005期
2. Liver transplantation for patients with hepatocellular carcinoma at the Liver Cancer Institute of Fudan University, China [J] . ZHOU Jian, HE Yi-feng, YANG Guo-huan, 中华医学杂志（英文版） . 2005,第008期
3. Unfair Advantages for Hepatocellular Carcinoma Patients Listed for Liver Transplant in Short-Wait Regions Following 2015 Hepatocellular Carcinoma Policy Change [J] . Brondfield Max N., Dodge Jennifer L., Hirose Ryutaro, Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society . 2020,第5期

机译：在2015年肝细胞癌政策变化后，短等待地区肝脏移植肝癌患者的不公平优势
4. Donor factors similarly impact survival outcome after liver transplantation in Hepatocellular carcinoma and non-Hepatocellular carcinoma patients [J] . SalgiaR.J., GoodrichN.P., MarreroJ.A., Digestive Diseases and Sciences . 2014,第1期

机译：肝细胞癌和非肝细胞癌患者的供体因素同样影响肝移植后的生存结果
5. Liver Transplant for Mixed Capillary-cavernous Hemangioma Masquerading as Hepatocellular Carcinoma in a Patient With Hepatocellular Carcinoma [J] . Ethem Unal, Franto Francis, Alger Aquino, Experimental and clinical transplantation . 2011,第5期

机译：在肝细胞癌患者中伪装成肝细胞癌的混合毛细血管-海绵状血管瘤的肝移植。
6. Surgical treatment for hepatocellular carcinoma: the role of living donor liver transplantation [C] . C. VALENTIN GAMAZ, C. E. BROELSCH, M. MALAGO Falk Workshop . 2003

机译：肝细胞癌的外科治疗：生活供体肝移植的作用
7. Macrotrabecular Massive, a Novel Hepatocellular Carcinoma Histological Subtype: Analysis of Post- Resection and Transplant Recurrence [D] . Jeon, Yejoo. 2019

机译：Macrootrabular巨大，一种新型肝细胞癌组织学亚型：分析切除后和移植复发
8. Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation [O] . Leonardo Lorente, Sergio T. Rodriguez, Pablo Sanz, 2019

机译：肝细胞癌患者肝移植前血清褪黑激素水平低与肝移植后存活率降低有关
9. Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation [O] . Leonardo Lorente, Sergio Rodriguez, Pablo Sanz, 2019

机译：在肝细胞癌患者肝移植之前，低血清褪黑激素水平与肝移植后较低的存活相关
10. Defining Hepatocellular Carcinoma Subtypes and Treatment Responses in Patient-Derived Tumorgrafts. [R] . Yopp, A., Zhu, H., Singal, A., 2017

机译：定义肝细胞癌亚型和患者来源的肿瘤移植物的治疗反应。

When to consider liver transplantation in hepatocellular carcinoma patients?

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