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Genotoxicity in Brazilian coal miners and its associated factors

机译：巴西煤矿工人的基因毒性及其相关因素

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摘要

The present study aims to evaluate the potential genotoxic and associated factors among coal miners, divided by degree of exposure. Blood and buccal smears were collected from 158 workers, who actively participate in different activities in coal mining, and 48 individuals living in the same city but do not have participation in coal mining activities (control group). The workers were divided into three different groups, according to the level of contact with coal extraction. A questionnaire intended to identify factors associated with DNA damage was performed in participants. The results regarding oral mucosa micronucleus test showed a significant difference (p 0.001) of the worker groups 1 and 2 in relation to the control group, where the group 1 has a higher degree of exposure to coal than group 2. For the lymphocyte micronucleus test and comet assay, there was no significant difference between the exposed groups and control group. There is an association between the outcome and the fact of living in the municipality of the mining company and the exposure to radiation in the last 12 months. Besides, the multivariate analysis showed an association of the tail moment with radiation exposure in the last 12 months. Thus, the findings of this study reveal genotoxicity in oral mucosa cells of workers exposed to coal and that workers with higher degree of contact with coal have a more pronounced response.
机译：本研究旨在评估煤矿工人中潜在的遗传毒性和相关因素，并根据暴露程度进行划分。从158名积极参与不同采煤活动的工人和48名居住在同一城市但没有参与采煤活动的个人（对照组）中收集血液和口腔涂片。根据接触煤炭开采的程度，工人被分为三个不同的组。在参与者中进行了一份旨在确定与DNA损伤相关因素的问卷调查。关于口腔粘膜微核试验的结果显示，工人组1和2与对照组相比存在显著差异（p；0.001），其中第1组接触煤炭的程度高于第2组。淋巴细胞微核试验和彗星试验，暴露组和对照组之间没有显著差异。在过去12个月里，居住在矿业公司所在城市的结果和事实与辐射暴露之间存在关联。此外，多变量分析显示，在过去12个月内，尾矩与辐射暴露有关。因此，这项研究的发现揭示了接触煤炭工人口腔粘膜细胞的遗传毒性，以及接触煤炭程度较高的工人有更明显的反应。

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