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Bisphenol A as a risk factor for allergic rhinitis in children

机译：双酚A作为儿童过敏性鼻炎的危险因素

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摘要

Aim: Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR. Methods: This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity. Results: Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis. Conclusions: The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity.
机译：目的：双酚A（BPA）是一种内分泌干扰物，可加重或诱发过敏性疾病。据我们所知，几乎没有证据表明BPA暴露对儿童过敏性鼻炎（AR）的影响。在本研究中，我们试图检查儿童接触BPA是否与AR相关。方法：本研究设计为病例对照临床研究。选择140名诊断为变应性鼻炎的儿童和140名健康儿童作为对照组。测定BPA、白细胞介素-4、白细胞介素-13、总IgE和干扰素γ水平。患者组进行皮肤点刺试验。鼻腔症状总分和ARIA分类用于预测疾病的严重程度。结果：变应性鼻炎患儿血清IL-4、IgE和BPA水平明显高于对照组。BPA和IL-4水平在中重度持续组显著升高。变应性鼻炎患儿的鼻腔症状总分与双酚a水平呈正相关。结论：本研究首次观察到BPA浓度与儿童变应性鼻炎之间有统计学意义的关系。BPA水平的升高也与疾病的严重程度有关。

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