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首页> 外文期刊>Zygote >Frozen-thawed cleavage stage versus blastocyst stage embryo transfer in high responder patients
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Frozen-thawed cleavage stage versus blastocyst stage embryo transfer in high responder patients

机译：冷冻解冻的切割阶段与高响应患者胚性阶段胚胎转移

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Clinical outcomes following frozen-thawed cleavage embryo transfer versus frozen-thawed blastocyst transfer in high responder patients undergoing in vitro fertilisation/intracytoplasmic sperm injection cycles are still debated. In a retrospective study, 106 high responder patients who were candidate for 'freeze-all embryos' were recruited. Frozen-thawed embryos were transferred at the cleavage stage (n = 53) or the blastocyst stage (n = 53). Clinical pregnancy was considered as the primary outcome and chemical pregnancy, ongoing pregnancy, implantation rate, and fertilization rate, as well as miscarriage rate, were measured as the secondary outcome. Clinical (47.2% vs. 24.5%), chemical (56.6% vs. 32.1%), and ongoing pregnancy rates (37.7% vs. 17%) as well as implantation rates (33.6% vs. 13.5%) were significantly higher in the blastocyst group compared with the cleavage group respectively (P < 0.05). Miscarriage rate was comparable between groups (P > 0.05). Transfer of frozen-thawed embryos at the blastocyst stage was preferable in the high responder patients to increase implantation, pregnancy and live birth rates compared with cleavage stage embryo transfer.
机译：在接受体外受精/胞浆内单精子注射周期的高反应患者中，冷冻-解冻卵裂胚胎移植与冷冻-解冻囊胚移植后的临床结果仍存在争议。在一项回顾性研究中，招募了106名高反应患者，他们是“冷冻所有胚胎”的候选者。冷冻解冻的胚胎在卵裂期（n=53）或胚泡期（n=53）进行移植。临床妊娠被视为主要结局，化学妊娠、持续妊娠、植入率、受精率以及流产率被视为次要结局。囊胚组的临床（47.2%对24.5%）、化学（56.6%对32.1%）、持续妊娠率（37.7%对17%）以及植入率（33.6%对13.5%）分别显著高于卵裂组（P<0.05）。两组间流产率具有可比性（P>0.05）。与卵裂期胚胎移植相比，在高反应患者中，在囊胚期移植冷冻解冻的胚胎更可取，以提高植入率、妊娠率和活产率。

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