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首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis
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Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis

机译：患者健康问卷9和患者健康问卷2在成人皮炎患者中的测量特性

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Background Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms. Objective We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted. Results PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82). Conclusions PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.
机译：研究背景：在评估AD患者抑郁症状时，很少有结果指标得到验证。患者健康问卷-9（PHQ9）和缩写的PHQ2是确定患者报告的抑郁症状结果指标。目的研究成人AD患者PHQ9和PHQ2的测量特性。对458例AD患者（年龄18-97岁）进行了一项基于皮肤科实践的前瞻性研究。结果PHQ9与皮肤病生活质量指数、患者报告结果测量信息系统（PROMIS）、睡眠障碍和睡眠相关障碍、PROMIS瘙痒问卷、情绪和睡眠（PIQ-MS）密切相关，与以患者为导向的湿疹测量、数字评分量表（NRS）平均瘙痒、NRS睡眠、湿疹面积和严重程度指数中度相关，得分AD和Rajka Langeland得分。PHQ2与PROMIS SD、SRI和PIQ-MS的相关性明显弱于PHQ9，但与其他结果的相关性相似。PHQ9和PHQ2具有良好的判别效度。PHQ9和PHQ2的基线变化与其他结果指标的变化相关性很差或很弱。PHQ项目的功能没有差异。PHQ9具有良好的信度（组内相关系数范围：0.80-0.87）。PHQ2的可靠性稍低（0.76-0.82）。结论PHQ9和PHQ2具有相似的测量特性，但PHQ2更适合评估AD患者的抑郁症状。

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