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首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Isothiazolinone Detection in Dish Soap and Personal Care Products: Comparison of Lovibond Isothiazolinone Test Kit and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry
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Isothiazolinone Detection in Dish Soap and Personal Care Products: Comparison of Lovibond Isothiazolinone Test Kit and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry

机译：Disothiazolinone检测在洗碗肥皂和个人护理产品中：Lovibond等噻唑啉酮测试套件和超高效液相色谱 - 串联质谱法

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Background Isothiazolinones are commonly used preservatives, which may cause allergic contact dermatitis. The Lovibond Isothiazolinone Test Kit (LITK) has been reported to successfully identify clinically relevant, occult isothiazolinones in patient personal care products. Objective The aim of the study was to analyze dish soaps and personal care products that do not declare isothiazolinones ("no-ISO") for the presence of isothiazolinones via 2 methods: LITK and ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Methods No-ISO dish soaps (n = 9), a convenience sample of patient products (n = 6), and controls (positive [isothiazolinone declared], n = 5; negative, n = 2) were tested with LITK (X3) and UHPLC-MS/MS. Results Several no-ISO dish soaps and personal products were positive for isothiazolinones (LITK, n = 12; UHPLC-MS/MS, n = 3). Ultrahigh-performance liquid chromatography-tandem mass spectrometry specifically identified methylisothiazolinone alone in 1 no-ISO dish soap, methylchloroisothiazolinone in another, and both in a third. Using UHPLC-MS/MS as the criterion standard, we observed the accuracy of LITK for 9 dish soaps was poor (sensitivity, 66.7%; specificity, 20%) and very poor for 6 personal care products (sensitivity, 0%; specificity, 0%). Conclusions Personal products may contain undeclared isothiazolinones. The current study found that LITK had poor accuracy for testing dish soap and personal care products. Clinicians should be aware of these factors when managing patients with contact allergy to isothiazolinones.
机译：背景异噻唑啉酮是常用的防腐剂，可引起过敏性接触性皮炎。据报道，洛维邦异噻唑啉酮检测试剂盒（LITK）可成功识别患者个人护理产品中与临床相关的隐匿性异噻唑啉酮。目的本研究的目的是通过两种方法：LITK和超高效液相色谱-串联质谱（UHPLC-MS/MS）分析未申报异噻唑啉酮（“无ISO”）的洗碗皂和个人护理产品中是否存在异噻唑啉酮。方法用LITK（X3）和UHPLC-MS/MS检测无ISO洗碗皂（n=9）、患者产品方便样品（n=6）和对照组（阳性[已申报的异噻唑啉酮]，n=5；阴性，n=2）。结果几种无ISO洗碗皂和个人产品对异噻唑啉酮呈阳性（LITK，n=12；UHPLC-MS/MS，n=3）。超高效液相色谱-串联质谱法特别鉴定了1号异硫唑啉酮单独存在于1号异硫唑啉香皂中，甲基氯异硫唑啉酮存在于另一种香皂中，二者均存在于第三种香皂中。以UHPLC-MS/MS为标准，我们观察到9种洗碗皂的LITK准确度较差（敏感性66.7%；特异性20%），6种个人护理产品的LITK准确度较差（敏感性0%；特异性0%）。结论个人产品可能含有未申报的异噻唑啉酮。目前的研究发现，LITK测试洗碗皂和个人护理产品的准确性较差。临床医生在治疗异噻唑啉酮接触性过敏患者时应注意这些因素。

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