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首页> 外文期刊>Developmental dynamics: an official publication of the American Association of Anatomists >Characterization of Glcci1 Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon
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Characterization of Glcci1 Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon

机译：小鼠瞳孔疗效侧神经神经神经神经神经神经神经节祖祖的亚沉积中GLCCI1 GLCCI1表达的特征

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Background : The lateral ganglionic eminence (LGE) in the ventral telencephalon is a diverse progenitor domain subdivided by distinct gene expression into a dorsal region (dLGE) that gives rise to olfactory bulb and amygdalar interneurons and a ventral region (vLGE) that gives rise to striatal projection neurons. The homeobox gene, Gsx2 , is an enriched marker of the LGE and is expressed in a high dorsal to low ventral gradient in the ventricular zone (VZ) as development proceeds. Aside from Gsx2, markers restricted to the VZ in the dLGE and/or vLGE remain largely unknown. Results : Here, we show that the gene and protein expression of Glucocorticoid‐induced transcript 1 ( Glcci1 ) has a similar dorsal to ventral gradient of expression in the VZ as Gsx2. We found that Glcci1 gene and protein expression are reduced in Gsx2 mutants, and are increased in the cortex after early and late Gsx2 misexpression. Moreover, Glcci1 expressing cells are restricted to a subpopulation of Gsx2 positive cells on the basal side of the VZ and co‐express Ascl1, but not the subventricular zone dLGE marker, Sp8. Conclusions : These findings suggest that Glcci1 is a new marker of a subpopulation of LGE VZ progenitor cells in the Gsx2 lineage. Developmental Dynamics 247:222–228, 2018 . ? 2017 Wiley Periodicals, Inc.
机译：背景：腹侧端脑的外侧神经节隆起（LGE）是一个由不同基因表达细分为背侧区（dLGE）和腹侧区（vLGE）的多种祖细胞结构域，前者产生嗅球和杏仁核中间神经元，后者产生纹状体投射神经元。同源框基因Gsx2是LGE的富集标记，随着发育的进行，它在心室区（VZ）以从背侧到腹侧的高梯度表达。除了Gsx2之外，dLGE和/或vLGE中仅限于VZ的标记在很大程度上仍然未知。结果：在这里，我们发现糖皮质激素诱导转录物1（Glcci1）的基因和蛋白质表达在VZ中的表达梯度与Gsx2相似。我们发现Gsx2突变体中Glcci1基因和蛋白表达降低，在Gsx2早期和晚期错误表达后，皮质中Glcci1基因和蛋白表达增加。此外，Glcci1表达细胞仅限于VZ基底侧的Gsx2阳性细胞亚群，并共同表达Ascl1，但不表达室下区dLGE标记物Sp8。结论：这些发现表明Glcci1是Gsx2谱系中LGE VZ祖细胞亚群的新标记物。发展动态247:222–2282018？2017威利期刊公司。

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