...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Developmental dynamics: an official publication of the American Association of Anatomists >Defining the critical period of hedgehog pathway inhibitor-induced cranial base dysplasia in mice
【24h】

Defining the critical period of hedgehog pathway inhibitor-induced cranial base dysplasia in mice

机译：定义刺猬途径抑制剂诱导的小鼠颅底发育不良的关键时期

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The hedgehog signaling pathway is critical for developmental patterning of the limb, craniofacial and axial skeleton. Disruption of this pathway in mice leads to a series of structural malformations, but the exact role and critical period of the Hh pathway in the early development of the cranial base have been rarely described.Results: Embryos exposed to vismodegib from E7.5, E9.5, and E10.5 had a higher percentage of cranial base fenestra. The peak incidence of hypoplasia in sphenoid winglets and severe craniosynostosis in cranial base synchondroses was observed when vismodegib was administered between E9.5 and E10.5. Cranial base craniosynostosis results from accelerating terminal differentiation of chondrocytes and premature osteogenesis.Conclusions: We define the critical periods for the induction of cranial base deformity by vismodegib administration at a meticulous temporal resolution. Our findings suggest that the Hh pathway may play a vital role in the early development of the cranial base. This research also establishes a novel and easy-to-establish mouse model of synostosis in the cranial base using a commercially available pathway-selective inhibitor.
机译：背景：刺猬信号通路对肢体、颅面部和轴向骨骼的发育模式至关重要。这种通路在小鼠体内的破坏会导致一系列结构畸形，但Hh通路在颅底早期发育中的确切作用和关键时期却鲜有描述。结果：胚胎暴露于E7的vismodegib。5，E9。5和E10。5例有较高比例的颅底开窗。在E9和E9之间使用vismodegib时，观察到蝶骨小翼发育不全和颅底软骨瘤严重颅缝愈合的峰值发生率。5和E10。5.颅底颅缝骨形成是加速软骨细胞终末分化和过早成骨的结果。结论：我们以精细的时间分辨率定义了vismodegib给药诱发颅底畸形的关键时期。我们的研究结果表明，Hh通路可能在颅底的早期发育中发挥重要作用。本研究还利用一种市售的通路选择性抑制剂建立了一种新的、易于建立的小鼠颅底骨性融合模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号