Lessons from joint development for cartilage repair in the clinic.

Thorup A-S; DellAccio F; Eldridge SE.

首页> 外文期刊>Developmental dynamics: an official publication of the American Association of Anatomists >Lessons from joint development for cartilage repair in the clinic.

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Lessons from joint development for cartilage repair in the clinic.

机译：临床软骨修复的联合开发的课程。

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More than 250 years ago, William Hunter stated that when cartilage is destroyed it never recovers. In the last 20 years, the understanding of the mechanisms that lead to joint formation and the knowledge that some of these mechanisms are reactivated in the homeostatic responses of cartilage to injury has offered an unprecedented therapeutic opportunity to achieve cartilage regeneration. Very large investments in ambitious clinical trials are finally revealing that, although we do not have perfect medicines yet, disease modification is a feasible possibility for human osteoarthritis.

机译：250多年前，威廉·亨特（William Hunter）表示，软骨一旦被破坏，就永远无法恢复。在过去20年中，对导致关节形成的机制的理解，以及对其中一些机制在软骨对损伤的稳态反应中被重新激活的认识，为实现软骨再生提供了前所未有的治疗机会。在雄心勃勃的临床试验中进行的大量投资终于表明，尽管我们还没有完美的药物，但对人类骨关节炎进行疾病改造是可行的。

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来源
《Developmental dynamics: an official publication of the American Association of Anatomists》 |2021年第3期|共17页
作者
Thorup A-S; DellAccio F; Eldridge SE.;
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作者单位

Centre for Experimental Medicine and Rheumatology William Harvey Research Institute Barts and the;

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原文格式 PDF
正文语种 eng
中图分类人体形态学;
关键词
cartilage regeneration; injury; joint development; osteoarthritis; stem cells; WNTs;

机译：软骨再生;伤害;联合发育;骨关节炎;干细胞;Wnts;

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3. Repairing articular cartilage defects with tissue-engineering cartilage in rabbits [J] . SONG Hong-xing, LI Fo-bao, SHEN Hui-liang, 中华创伤杂志（英文版） . 2006,第005期
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10. Lessons from joint development for cartilage repair in the clinic [O] . Anne‐Sophie Thorup, Francesco DellAccio, Suzanne E. Eldridge 2020

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11. Evaluation of Joint Repair Methods for Cast Iron Natural Gas Distribution Mains and the Preliminary Development of an Alternative Joint Seal [R] . Rogers, T. E. , Glicksman, L. R. , Peterson, C. R. 1984

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Lessons from joint development for cartilage repair in the clinic.

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