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首页> 外文期刊>Diagnostic cytopathology >The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases
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The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases

机译：温州温州人乳头瘤病毒和宫颈细胞学的患病率，基因型分布：7391例回顾性研究

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摘要

Background Human papillomavirus (HPV) infection is the main pathogen of precancerous transformation and finally progress to cervical cancer. It associated with cervical squamous and glandular lesions. However, the genotype distribution of HPV and the relationship between HPV infection and cervical disease are still remind unclear. Material and methods A total of 7391 abnormal cervical cytology cases with detailed histological reports and HPV genotypes were collected. The prevalence of HPV infection in squamous epithelial lesions and glandular epithelial lesions were statistically analyzed. Result Around 6958 cytological squamous epithelial lesions and 433 glandular epithelial lesions were enrolled. 79.72% of cytological squamous epithelial lesions and 26.56% of glandular epithelial lesions were HPV infected. The HPV infection rates in squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma were 66.67%, 54.17% and 19.72%, respectively. HVP16, 18 and 58 are the most common types in squamous and glandular epithelial lesions. Among the squamous epithelial lesions, women less than 25 years old had the highest HPV infection rate, and majority of multiple infections was found in women >55 years old. The total infection rate of HPV in glandular epithelial lesions was the highest in the 35 to 45 group. Multiple infections peaked in women around 55 years old. Conclusion The prevalence of HPV infection is divergent in different types of cervical cancer. The HPV infections in cervical squamous epithelial lesions tended to be younger. HPV detection is one of the necessary tests for cervical disease screening and should be individualized in an age manner.
机译：背景：人类乳头瘤病毒（HPV）感染是癌前转化并最终发展为宫颈癌的主要病原体。它与宫颈鳞状上皮和腺体病变有关。然而，HPV的基因型分布以及HPV感染与宫颈疾病之间的关系仍不清楚。材料与方法收集7391例宫颈细胞学异常病例，包括详细的组织学报告和HPV基因型。统计分析鳞状上皮病变和腺上皮病变中HPV感染的患病率。结果共纳入6958例细胞学鳞状上皮病变和433例腺上皮病变。79.72%的细胞学鳞状上皮病变和26.56%的腺上皮病变为HPV感染。鳞状细胞癌、宫颈腺癌和子宫内膜腺癌中HPV感染率分别为66.67%、54.17%和19.72%。HVP16、18和58是鳞状上皮和腺上皮病变中最常见的类型。在鳞状上皮病变中，25岁以下的女性HPV感染率最高，大多数多重感染发生在55岁以上的女性。腺上皮病变中HPV的总感染率在35-45组中最高。多重感染在55岁左右的女性中达到高峰。结论不同类型宫颈癌HPV感染率存在差异。宫颈鳞状上皮病变中HPV感染呈年轻化趋势。HPV检测是宫颈疾病筛查的必要检测之一，应按年龄进行个体化。

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  • 来源
    《Diagnostic cytopathology》 |2021年第2期|共8页
  • 作者

    Lin Qiongqiong; Lin Xiangjie; Zhuang Xiaoping; Tang Yibing; Zhao Zhiguang;

  • 作者单位

    Wenzhou Med Sch Dept Pathol Affiliated Hosp 2 109 Xueyuan Western Rd Wenzhou 325000 Peoples R;

    Wenzhou Med Sch Dept Pathol Affiliated Hosp 2 109 Xueyuan Western Rd Wenzhou 325000 Peoples R;

    Wenzhou Hosp Integrated Tradit Chinese &

    Western Dept Pathol Wenzhou PR Peoples R China;

    Wenzhou Med Sch Dept Pathol Affiliated Hosp 2 109 Xueyuan Western Rd Wenzhou 325000 Peoples R;

    Wenzhou Med Sch Dept Pathol Affiliated Hosp 2 109 Xueyuan Western Rd Wenzhou 325000 Peoples R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

    cervical cytology; genotype distribution; HPV; prevalence;

    机译：宫颈细胞学;基因型分布;HPV;流行;

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