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首页> 外文期刊>Digestive Diseases and Sciences >Low Epstein-Barr Virus Prevalence in Cardia Gastric Cancer Among a High-Incidence Chinese Population
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Low Epstein-Barr Virus Prevalence in Cardia Gastric Cancer Among a High-Incidence Chinese Population

机译：贲门胃癌中低发病率的低发病率患病率低

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Background Epstein-Barr virus (EBV) positivity is associated with better gastric cancer prognosis and is found in a relatively fixed 9% of tumors worldwide. Aim We aimed to examine the EBV status of gastric adenocarcinomas in a very high-incidence population and to compare prevalence between cardia and non-cardia anatomic subsites. Methods We evaluated 1035 adult gastric adenocarcinoma cases presenting during 1997-2005 to the Shanxi Cancer Hospital in Taiyuan, Shanxi Province, China. EBV-encoded RNA was detected in alcohol-fixed paraffin-embedded tumor specimens by in situ hybridization. Associations were assessed in case-case comparisons using the Chi-squared test for categorical variables and the Mann-Whitney U test for continuous variables, with p values < 0.05 considered statistically significant. Adjusted odds ratios were calculated using logistic regression, and mortality hazard ratios (HRs) were estimated by Cox proportional hazards regression. Results Sixty-four percent of the evaluated cancers were found in the cardia. Cardia tumor localization was associated with male sex, advanced primary tumor stage, better differentiated histology, and intestinal-type Lauren classification. Four percent of the non-cardia and only 0.9% of cardia cancers were EBV-positive. EBV positivity was associated with better overall survival (adjusted HR 0.30, 95% CI 0.14-0.63). Conclusions Our study highlights unusually low EBV prevalence in gastric adenocarcinoma among a high-incidence population, particularly for cardia cancers. These findings suggest a unique risk factor profile for the high incidence of gastric cancer in this population.
机译：背景：EB病毒（EBV）阳性与更好的胃癌预后相关，在全世界相对固定的9%的肿瘤中发现。目的研究胃癌高发人群的EBV状态，并比较贲门和非贲门解剖亚群的患病率。方法我们评估了山西省太原市肿瘤医院1997-2005年收治的1035例成人胃腺癌病例。用原位杂交法在酒精固定的石蜡包埋的肿瘤标本中检测到EBV编码的RNA。在病例比较中使用卡方检验对分类变量进行评估，使用Mann-Whitney U检验对连续变量进行评估，p值<0.05被认为具有统计学意义。调整后的优势比用逻辑回归计算，死亡率风险比（HRs）用Cox比例风险回归估计。结果64%的评估癌症发生在贲门。贲门肿瘤定位与男性、晚期原发性肿瘤分期、更好的分化组织学和肠道类型Lauren分类有关。4%的非贲门癌和0.9%的贲门癌EBV阳性。EBV阳性与更好的总体生存率相关（校正HR 0.30，95%可信区间0.14-0.63）。结论我们的研究强调，在高发人群中，尤其是贲门癌中，胃腺癌的EBV患病率异常低。这些发现表明，在这一人群中，胃癌的高发病率具有独特的风险因素特征。

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