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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection
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Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection

机译：Epigallocatechin Gallate抑制猕猴的Sevi介导的SIV或SHIV感染的增强

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摘要

Background: Human semen contains a factor that can enhance HIV infection up to 10(5)-fold in cultures. This factor is termed semen-derived enhancer of virus infection (SEVI) and is composed of proteolytic fragments (PAP248-286) from prostatic acid phosphatase in semen. In this study, we examined whether macaque SEVI can facilitate simian immunodeficiency virus (SIV) or chimeric simian/human immunodeficiency virus (SHIV) infection. We also studied the effect of epigallocatechin gallate (EGCG) on macaque SEVI-mediated SIV or SHIV enhancement.
机译：背景：人类精液中含有一种因子，在培养基中可使HIV感染增加10（5）倍。该因子被称为精液源性病毒感染增强子（SEVI），由精液中前列腺酸性磷酸酶的蛋白水解片段（PAP248-286）组成。在这项研究中，我们检测了猕猴SEVI是否能促进猴免疫缺陷病毒（SIV）或嵌合猴/人类免疫缺陷病毒（SHIV）感染。我们还研究了表没食子儿茶素没食子酸酯（EGCG）对猕猴SEVI介导的SIV或SHIV增强的影响。

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  • 作者

    Zhou Run-Hong; Guo Le; Liu Jin-Biao; Liu Hang; Hou Wei; Ma Tong-Cui; Wang Xu; Wu Jian-Guo; Ye Li; Ho Wen-Zhe; Li Jie-Liang;

  • 作者单位

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Temple Univ Lewis Katz Sch Med Dept Pathol &

    Lab Med MERB 808B 3500 North Broad St Philadelphia;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Nanning Peoples R China;

    Wuhan Univ Sch Basic Med Sci State Key Lab Virol Wuhan Peoples R China;

    Temple Univ Lewis Katz Sch Med Dept Pathol &

    Lab Med MERB 808B 3500 North Broad St Philadelphia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    SEVI; macaque; SIV; SHIV; EGCG; amyloid fibrils;

    机译：sevi;macaque;siv;shiv;egcg;淀粉样蛋白原纤维;

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