Effect of Long-Acting Injectable Antipsychotics vs Usual Care on Time to First Hospitalization in Early-Phase Schizophrenia A Randomized Clinical Trial

Ilgen Mark A.; Coughlin Lara N.; Bohnert Amy S. B.; Chermack Stephen; Price Amanda; Kim H. Myra; Jannausch Mary; Blow Frederic C.

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Effect of Long-Acting Injectable Antipsychotics vs Usual Care on Time to First Hospitalization in Early-Phase Schizophrenia A Randomized Clinical Trial

机译：长效可注射抗精神病药效果对早期精神分裂症的第一次住院治疗随机临床试验

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Question Compared with usual care, does the use of a long-acting formulation of antipsychotic medication reduce the risk of hospitalization in early-phase schizophrenia? Findings In this cluster randomized trial of 489 participants, use of long-acting injectable aripiprazole monohydrate was associated with a significant delay in time to first hospitalization, with the number needed to treat to prevent 1 hospitalization of 7. Meaning Long-acting formulations are infrequently used in early-phase treatment, and the association between their use and decreased hospitalization risk can have implications for individual treatment decisions and public health efforts.

机译：问题：与常规护理相比，使用长效抗精神病药物是否能降低早期精神分裂症患者住院的风险？在这项489名参与者的集群随机试验中发现，使用长效注射型阿立哌唑一水合物与首次住院时间的显著延迟相关，7人中有1人需要治疗才能避免住院。这意味着长效制剂很少用于早期治疗，其使用与住院风险降低之间的关联可能对个体治疗决策和公共卫生工作产生影响。

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《JAMA psychiatry》 |2020年第12期|共10页
作者
Ilgen Mark A.; Coughlin Lara N.; Bohnert Amy S. B.; Chermack Stephen; Price Amanda; Kim H. Myra; Jannausch Mary; Blow Frederic C.;
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VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

Univ Michigan Dept Psychiat Med Sch Ann Arbor MI 48109 USA;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

VA Ctr Clin Management Res CCMR Dept Vet Affairs Healthcare Syst 2800 Plymouth Rd Ann Arbor MI;

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正文语种 eng
中图分类神经病学与精神病学;
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机译：长效可注射抗精神病学的影响对早期精神分裂症的第一次住院时间常规护理：随机临床试验（JUL，10.1001 / JAMAPSYCHIATRY.2020.2076,2020）
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Effect of Long-Acting Injectable Antipsychotics vs Usual Care on Time to First Hospitalization in Early-Phase Schizophrenia A Randomized Clinical Trial

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