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首页> 外文期刊>Journal of Analytical Toxicology >Free and Glucuronide Urine Cannabinoids after Controlled Smoked, Vaporized and Oral Cannabis Administration in Frequent and Occasional Cannabis Users
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Free and Glucuronide Urine Cannabinoids after Controlled Smoked, Vaporized and Oral Cannabis Administration in Frequent and Occasional Cannabis Users

机译：在频繁和偶尔的大麻用户中，在受控烟熏，蒸发和口服大麻管理后，免费和葡萄糖醛尿尿尿壶尿壶

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摘要

Total urinary 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) concentrations are generally reported following cannabis administration. Few data are available for glucuronide and minor cannabinoid metabolite concentrations. All urine specimens from 11 frequent and 9 occasional cannabis users were analyzed for 11 cannabinoids for similar to 85 h by liquid chromatography with tandem mass spectrometry following controlled smoked, vaporized or oral 50.6 mg Delta(9)-tetrahydrocannabinol (THC) in a randomized, placebo-controlled, within-subject dosing design. No cannabidiol, cannabinol, cannabigerol, tetrahydrocannabivarin (THCV), THC, 11-OH-THC and Delta(9)-tetrahydrocannabinolic acid were detected in urine. Median THCCOOH-glucuronide maximum concentrations (C-max) following smoked, vaporized and oral routes were 68.0, 26.7 and 360 mu g/L for occasional and 378, 248 and 485 mu g/L for frequent users, respectively. Median time to specific gravity-normalized C-max (T-max) was 5.1-7.9 h for all routes and all users. Median C-max for THCCOOH, THC-glucuronide and 11-nor-9-carboxy-Delta(9)-THCV (THCVCOOH) were <7.5% of THCCOOH-glucuronide C-max concentrations. Only THC-glucuronide mean T-max differed between routes and groups, and was often present only in occasional users' first urine void. Multiple THCCOOH-glucuronide and THCCOOH peaks were observed. We also evaluated these urinary data with published models for determining recency of cannabis use. These urinary cannabinoid marker concentrations from occasional and frequent cannabis users following three routes of administration provide a scientific database to assess single urine concentrations in cannabis monitoring programs. New target analytes (CBD, CBN, CBG, THCV and phase II metabolites) were not found in urine. The results are important to officials in drug treatment, workplace and criminal justice drug monitoring programs, as well as policy makers with responsibility for cannabis regulations.
机译：服用大麻后，通常会报告尿液中11-去甲-9-羧基-四氢大麻酚（THCCOOH）的总浓度。关于葡糖苷酸和少量大麻素代谢物浓度的数据很少。采用随机、安慰剂对照、受试者内给药设计，在对照吸烟、蒸发或口服50.6 mgδ（9）-四氢大麻酚（THC）后，通过液相色谱-串联质谱法，对11名经常服用大麻和9名偶尔服用大麻者的所有尿液样本进行了11种大麻素的分析，分析时间类似于85小时。尿液中未检测到大麻酚、大麻酚、大麻酚、四氢大麻酚（THCV）、THC、11-OH-THC和δ（9）-四氢大麻酚酸。烟熏、蒸发和口服途径的THCCOOH葡萄糖醛酸苷最大浓度中位数（C-max）分别为68.0、26.7和360μg/L（偶尔使用）和378、248和485μg/L（经常使用）。对于所有路线和所有用户，达到比重标准化C-max（T-max）的平均时间为5.1-7.9小时。THCCOOH、THC葡糖苷酸和11-nor-9-羧基-Delta（9）-THCV（THCVCOOH）的C-max中值小于THCCOOH葡糖苷酸C-max浓度的7.5%。只有THC葡糖苷酸平均T-max在不同途径和组之间存在差异，并且通常仅出现在偶尔使用者的第一次尿空中。观察到多个THCCOOH葡糖苷酸和THCCOOH峰。我们还使用已发表的模型评估了这些尿液数据，以确定大麻使用的近期情况。这些偶尔和经常服用大麻者的尿液大麻素标记物浓度遵循三种给药途径，为评估大麻监测项目中的单次尿液浓度提供了一个科学数据库。在尿液中未发现新的目标分析物（CBD、CBN、CBG、THCV和II期代谢物）。研究结果对药物治疗、工作场所和刑事司法药物监测项目的官员以及负责大麻监管的政策制定者都很重要。

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  • 来源
    《Journal of Analytical Toxicology》 |2020年第7期|共10页
  • 作者

    Huestis Marilyn A.; Sempio Cristina; Newmeyer Matthew N.; Andersson Maria; Barnes Allan J.; Abulseoud Osama A.; Blount Benjamin C.; Schroeder Jennifer; Smith Michael L.;

  • 作者单位

    NIDA Chem &

    Drug Metab Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    NIDA Chem &

    Drug Metab Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    NIDA Chem &

    Drug Metab Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    NIDA Chem &

    Drug Metab Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    NIDA Chem &

    Drug Metab Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    NIDA Intramural Res Program NIH 5500 Nathan Shock Dr Baltimore MD 21224 USA;

    Ctr Dis Control &

    Prevent Natl Ctr Environm Hlth Div Lab Sci Tobacco &

    Volatiles Branch 4770;

    NIDA Off Clin Director Intramural Res Program NIH 251 Bayview Blvd Baltimore MD 21224 USA;

    Huestis &

    Smith Toxicol LLC 683 Shore Rd Severna Pk MD 21146 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
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