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首页> 外文期刊>Journal of Analytical Toxicology >Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Delta(9)-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females
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Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Delta(9)-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females

机译：大麻的药代动力学果仁植物：对健康成年男性和女性的血液和口服液中的δ（9） - 四氢甘露那酚和代谢物的受控检查

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摘要

Oral cannabis products (a.k.a. "edibles") have increased in popularity in recent years. Most prior controlled pharmacokinetic evaluations of cannabis have focused on smoked cannabis and included males who were frequent cannabis users. In this study, 17 healthy adults (8 females), with no cannabis use in at least the past 2 months, completed 4 double-blind outpatient sessions where they consumed cannabis brownies containing Delta(9)-tetrahydrocannabinol (THC) doses of 0, 10, 25 or 50 mg. Whole blood and oral fluid specimens were collected at baseline and for 8 h post-brownie ingestion. Enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) were used to measure THC and relevant metabolites. In whole blood, concentrations of THC and 11-hydroxy-THC (11-OH-THC) peaked 1.5-2 h after brownie consumption, decreased steadily thereafter, and typically returned to baseline within 8 h. Blood concentrations for 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide were higher than THC and 11-OH-THC and these metabolites were often still detected 8 h post-brownie consumption. Women displayed higher peak concentrations for THC and all metabolites in whole blood compared to men, at least partially owing to their lower body weight/body mass index. Detection of THC in oral fluid was immediate and appeared to reflect the degree of cannabis deposition in the oral cavity, not levels of THC circulating in the blood. THC concentrations were substantially higher in oral fluid than in blood; the opposite trend was observed for THCCOOH. Agreement between ELISA and LC-MS-MS results was high (i.e., over 90%) for blood THCCOOH and oral fluid THC but comparatively low for oral fluid THCCOOH (i.e., 67%). Following oral consumption of cannabis, THC was detected in blood much later, and at far lower peak concentrations, compared to what has been observed with inhaled cannabis. These results are important given the widespread use of toxicological testing to detect recent use of cannabis and/or to identify cannabis intoxication.
机译：近年来，口服大麻产品（又称“食用品”）越来越受欢迎。之前对大麻的大多数受控药代动力学评估都集中在吸食大麻上，并包括经常吸食大麻的男性。在这项研究中，17名健康成年人（8名女性），至少在过去2个月内没有使用大麻，完成了4次双盲门诊治疗，他们食用含有0、10、25或50 mgδ（9）-四氢大麻酚（THC）剂量的大麻布朗尼。在基线检查时和摄入布朗尼后8小时收集全血和口服液样本。采用酶联免疫吸附试验（ELISA）和液相色谱-串联质谱（LC-MS-MS）测定THC及其代谢产物。在全血中，THC和11-羟基THC（11-OH-THC）的浓度在食用布朗尼后1.5-2小时达到峰值，此后稳步下降，11-nor-9-羧基-Delta（9）-四氢大麻酚（THCCOOH）和THCCOOH-葡糖苷酸的血药浓度高于THC和11-OH-THC，且在食用布朗尼后8小时，通常仍能检测到这些代谢物。与男性相比，女性全血中THC和所有代谢物的峰值浓度更高，至少部分原因是她们的体重/体重指数较低。口服液中THC的检测是即时的，似乎反映了大麻在口腔中沉积的程度，而不是血液中循环的THC水平。口服液中的THC浓度明显高于血液中的THC浓度；在THCCOOH中观察到相反的趋势。ELISA和LC-MS-MS结果之间的一致性在血液THCCOOH和口服液THC中较高（即超过90%），但在口服液THCCOOH中相对较低（即67%）。与吸入大麻相比，口服大麻后，血液中检测到THC的时间要晚得多，峰值浓度要低得多。鉴于毒理学测试在检测近期大麻使用情况和/或确定大麻中毒方面的广泛使用，这些结果非常重要。

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  • 来源
    《Journal of Analytical Toxicology》 |2020年第7期|共11页
  • 作者

    Spindle Tory R.; Cone Edward J.; Herrmann Evan S.; Mitchell John M.; Flegel Ronald; LoDico Charles; Bigelow George E.; Vandrey Ryan;

  • 作者单位

    Johns Hopkins Univ Behav Pharmacol Res Unit Sch Med 5510 Nathan Shock Dr Baltimore MD 21224 USA;

    Johns Hopkins Univ Behav Pharmacol Res Unit Sch Med 5510 Nathan Shock Dr Baltimore MD 21224 USA;

    Johns Hopkins Univ Behav Pharmacol Res Unit Sch Med 5510 Nathan Shock Dr Baltimore MD 21224 USA;

    RTI Int 3040 East Cornwallis Rd Res Triangle Pk NC 27709 USA;

    Subst Abuse &

    Mental Hlth Serv Adm SAMHSA Div Workpl Programs DWP 5600 Fishers Lane Rockville;

    Subst Abuse &

    Mental Hlth Serv Adm SAMHSA Div Workpl Programs DWP 5600 Fishers Lane Rockville;

    Johns Hopkins Univ Behav Pharmacol Res Unit Sch Med 5510 Nathan Shock Dr Baltimore MD 21224 USA;

    Johns Hopkins Univ Behav Pharmacol Res Unit Sch Med 5510 Nathan Shock Dr Baltimore MD 21224 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
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