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首页> 外文期刊>Journal of Animal Physiology and Animal Nutrition >Nano zinc supplementation in goat (Capra hircus) ration improves immunity, serum zinc profile and IGF-1 hormones without affecting thyroid hormones
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Nano zinc supplementation in goat (Capra hircus) ration improves immunity, serum zinc profile and IGF-1 hormones without affecting thyroid hormones

机译：山羊（Capra Hircus）的纳米锌补充剂改善了免疫，血清曲线和IGF-1激素而不影响甲状腺激素

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The trial was aimed at evaluating probable superiority, if any of nano zinc (NZn) over inorganic zinc (Zn) on immunity, serum minerals and T-3, T-4, and IGF-1 hormone profiles in goats. NZn was synthesized by using 0.45 M aqueous solution of Zn nitrate and 0.9 M aqueous solution of sodium hydroxide (average particle size 74 nm). Twenty-four male goats were grouped into four groups as per their body weight and were supplemented with either a basal diet with concentrate and straw at 50:50 ratio (Negative control, NC) alone or supplemented with 50 mg/kg Zn (Control) from inorganic Zn source, that is ZnO (IZn-50), 50 mg/kg Zn from NZn (NZn-50) or 25 mg/kg Zn from NZn (NZn-25). No change was observed in thyroid hormone status on zero and 90th day of experimental feeding, but NZn supplementation improved (p < 0.05) IGF-1 level on 90th day serum samples. Zn supplementation improved the humoral immunity in all the groups irrespective of the source. Similarly, cell-mediated immunity (CMI) measured by skinfold thickness after injecting Con-A, was also improved in Zn supplemented groups than control at 6, 12 and 48 h of incubation. NZn-50 animals showed highest HI (haemagglutination inhibition) titre as well as skin thickness. The CD4+ (cluster of differentiation in %) was more (p < 0.05) in Zn supplemented groups. NZn-50 showed higher (p < 0.05) CD8+ count than NC and similar (p > 0.05) to IZn-50 and NZn-25 groups without affecting (p > 0.05) the ratio of CD4+, CD8+ among the treatment groups. Thus, NZn supplementation at 25 mg/kg had similar immunity and serum T-3, T-4 and IGF-1 profiles compared with IZn at 50 mg/kg dose.
机译：该试验旨在评估纳米锌（NZn）在免疫、血清矿物质以及山羊T-3、T-4和IGF-1激素水平上可能优于无机锌（Zn）的优势。NZn是用0.45M硝酸锌水溶液和0.9m氢氧化钠水溶液（平均粒径74nm）合成的。24只公山羊按体重分为四组，分别以50:50的比例（阴性对照，NC）单独添加精料和稻草的基础日粮，或添加无机锌源的50 mg/kg锌（对照），即ZnO（IZn-50）、NZn（NZn-50）的50 mg/kg锌或NZn（NZn-25）的25 mg/kg锌。在实验喂养的第0天和第90天，未观察到甲状腺激素状态的变化，但补充NZn改善了第90天血清样本中的IGF-1水平（p<0.05）。补充锌改善了所有组的体液免疫，无论来源如何。同样，通过注射Con-A后的皮褶厚度测量的细胞介导免疫（CMI）在培养6、12和48小时时，补充锌组也比对照组有所改善。NZn-50动物的HI（血凝抑制）滴度和皮肤厚度最高。补充锌组的CD4+（分化簇百分比）更多（p<0.05）。NZn-50的CD8+计数高于NC组（p<0.05），与IZn-50和NZn-25组相似（p>0.05），但不影响治疗组间CD4+、CD8+的比率（p>0.05）。因此，与50 mg/kg剂量的IZn相比，25 mg/kg剂量的NZn补充剂具有相似的免疫力和血清T-3、T-4和IGF-1水平。

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