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首页> 外文期刊>Journal of applied toxicology >Mechanisms and individuality in chromium toxicity in humans
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Mechanisms and individuality in chromium toxicity in humans

机译：人体中铬毒性的机制和个性

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摘要

With regards to health, chromium (Cr) is an ambiguous chemical element. Although it is considered to be an important micronutrient, it also is connected with several pathologies, including carcinogenicity. The mechanism of action of Cr and its compounds in humans is not yet fully understood. Currently, three possible mechanisms have been proposed for carcinogenesis: Cr(VI)-induced multistage carcinogenesis, genomic instability, and epigenetic modification. Therefore, in addition to the toxicity of this metal and its ions, human susceptibility to Cr-induced pathologies depends on external factors and individual characteristics, such as enzymatic polymorphisms, carriers, endogenous reducing system, adduct formation and stability, and efficiency of DNA repair mechanisms, among other factors. In fact, the variability of individual molecular constitutive factors, such as individual polymorphisms, creates an individualized environment for Cr toxicity. This mini-review contemplates the essential variables in this process.
机译：就健康而言，铬（Cr）是一种模棱两可的化学元素。虽然它被认为是一种重要的微量营养素，但它也与多种病理学有关，包括致癌性。铬及其化合物在人体内的作用机制尚不完全清楚。目前，有三种可能的致癌机制被提出：Cr（VI）诱导的多阶段致癌、基因组不稳定性和表观遗传修饰。因此，除了这种金属及其离子的毒性外，人类对铬诱导的疾病的易感性还取决于外部因素和个体特征，例如酶的多态性、载体、内源性还原系统、加合物的形成和稳定性，以及DNA修复机制的效率等因素。事实上，个体分子构成因素的可变性，如个体多态性，为铬毒性创造了个体化环境。这篇小评论考虑了这个过程中的基本变量。

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